Digitalis schischkinii
Species
KNApSAcK Entry
| Organism name | Digitalis schischkinii |
|---|---|
| Genus | Digitalis |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Digitalis |
|---|---|
| Linked NCBI taxonomy ID | 4163 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003838
|
Pectolinarigenin
|
CHEMBL78010
|
C079207
|
31 / 27 / 19 | No. 3 | No. 15 |
|
|
|
C00003885
|
Nepetin
/ Eupafolin / 6-Methoxyluteolin |
CHEMBL172350
|
31 / 34 / 60 | No. 3 | No. 15 |
|
||
|
C00003890
|
Jaceosidin
/ 5,7,4'-Trihydroxy-6,3'-dimethoxyflavone |
CHEMBL487601
|
C477508
|
1 / 0 / 0 | No. 3 | No. 15 |
|
Human Protein / Gene in interactions
54 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003838 C00003885 | 4 / 3 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00003838 C00003885 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003838 C00003885 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003838 C00003885 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003838 C00003885 | 1 / 2 |
| O00255 | Menin | Unclassified protein | C00003838 C00003885 | 2 / 5 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00003838 C00003885 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003838 C00003885 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003838 C00003885 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00003885 | 7 / 37 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003885 | 2 / 3 |
| P39748 | Flap endonuclease 1 | Enzyme | C00003885 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003885 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00003838 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003838 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00003838 | 4 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003885 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00003838 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003885 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003885 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00003885 | 0 / 0 |
| P04745 | Alpha-amylase 1 | Enzyme | C00003885 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003885 | 3 / 1 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00003885 | 1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00003885 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00003885 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00003885 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00003885 | 1 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00003885 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00003885 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00003885 | 0 / 0 |
| P59538 | Taste receptor type 2 member 31 | Taste receptor (taste family GPCR) | C00003890 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00003885 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00003885 | 6 / 4 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00003838 | 0 / 0 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003838 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003838 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00003838 | 0 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00003838 | 0 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00003838 | 1 / 0 |
| P04350 | Tubulin beta-4A chain | Structural | C00003838 | 2 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00003838 | 0 / 0 |
| P07437 | Tubulin beta chain | Structural | C00003838 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00003838 | 1 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00003838 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00003838 | 2 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00003885 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00003885 | 2 / 1 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00003838 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00003838 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00003838 | 0 / 0 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00003838 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00003838 | 0 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00003838 | 1 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (52)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #133239 | Esophageal cancer |
P04637
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (65)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|