| Organism name | Senna spectabilis | 
|---|---|
| Genus | Senna | 
| Family | Fabaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Senna spectabilis | 
|---|---|
| Linked NCBI taxonomy ID | 347003 | 
| Linked level | species | 
| Family in NCBI taxonomy | Fabaceae | 
|---|---|
| ID | 3803 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | 
                        # of proteins in
                         ChEMBL interaction / related OMIM / related KEGG DISEASE  | 
                      
                        # of genes in
                         CTD interaction / related diseases  | 
                      
                        KCF-S
                         cluster  | 
                      
                        phytochemical
                         cluster  | 
                      figure | 
|---|---|---|---|---|---|---|---|---|
| 
                        C00020681
                        
                           | 
                      
                        6-Hydroxy-4'-methoxyflavone 6-O-alpha-L-arabinopyranoside
                         | 
                      No. 2 | No. 15 | 
                         
                       | 
                    ||||
| 
                        C00004370
                        
                           | 
                      
                        Luteolin 7,3'-dimethyl ether 5-glucoside
                         | 
                      No. 2 | No. 15 | 
                         
                       | 
                    ||||
| 
                        C00005623
                        
                           | 
                      
                        Quercetin 7,3',4'-trimethyl ether 3-alpha-L-arabinopyranoside
                         | 
                      No. 2 | No. 15 | 
                         
                       | 
                    ||||
| 
                        C00000568
                        
                           | 
                      
                        Chrysophanol
                         | 
                      
                        CHEMBL41092
                         | 
                      
                        C027113
                         | 
                      20 / 17 / 20 | 1 / 0 | No. 41 | No. 62 | 
                         
                       | 
                    
| 
                        C00029288
                        
                           | 
                      
                        (-)-Spectaline
                         | 
                      
                        CHEMBL249464
                         CHEMBL487594  | 
                      No. 1887 | No. 1 | 
                         
                       | 
                    |||
| 
                        C00038042
                        
                           | 
                      
                        (-)-3-O-Acetylspectaline
                         | 
                      
                        CHEMBL251644
                         | 
                      No. 1887 | No. 1 | 
                         
                       | 
                    |||
| 
                        C00038068
                        
                           | 
                      
                        (+)-3-O-Feruloylcassine
                         | 
                      
                        CHEMBL249463
                         | 
                      No. 8335 | 
                         
                       | 
                    
| accession | description | class description | KNApSAcK metabolite in interactions | 
                          # of diseases
                           (OMIM / KEGG)  | 
                      
|---|---|---|---|---|
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000568 | 0 / 0 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000568 | 3 / 2 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00000568 | 2 / 3 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000568 | 0 / 0 | 
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000568 | 4 / 2 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000568 | 0 / 0 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00000568 | 0 / 1 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000568 | 0 / 0 | 
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000568 | 0 / 0 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000568 | 0 / 1 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000568 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000568 | 4 / 3 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000568 | 0 / 0 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000568 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000568 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000568 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000568 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000568 | 1 / 1 | 
| O00255 | Menin | Unclassified protein | C00000568 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000568 | 1 / 2 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor | 
                          C00000568
                           | 
                      
| OMIM | preferred title | UniProt | 
|---|---|---|
| #114480 | Breast cancer | 
                            P38398
                             | 
                        
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 | 
                            P38398
                             | 
                        
| #600274 | Frontotemporal dementia; ftd | 
                            P10636
                             | 
                        
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | 
                            Q03164
                             | 
                        
| #145000 | Hyperparathyroidism 1; hrpt1 | 
                            O00255
                             | 
                        
| #603373 | Hyperthyroidism, familial gestational | 
                            P16473
                             | 
                        
| #609152 | Hyperthyroidism, nonautoimmune | 
                            P16473
                             | 
                        
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | 
                            P16473
                             | 
                        
| #131100 | Multiple endocrine neoplasia, type i; men1 | 
                            O00255
                             | 
                        
| #607948 | Mycobacterium tuberculosis, susceptibility to | 
                            P11473
                             | 
                        
| #167000 | Ovarian cancer | 
                            P38398
                             | 
                        
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 | 
                            P38398
                             | 
                        
| #260540 | Parkinson-dementia syndrome | 
                            P10636
                             | 
                        
| #172700 | Pick disease of brain | 
                            P10636
                             | 
                        
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | 
                            Q9NUW8
                             | 
                        
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | 
                            P10636
                             | 
                        
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | 
                            P11473
                             | 
                        
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | 
                            O00255
                            (related)
                             | 
                        
| H00034 | Carcinoid | 
                            O00255
                            (related)
                             | 
                        
| H00045 | Malignant islet cell carcinoma | 
                            O00255
                            (related)
                             | 
                        
| H00246 | Primary hyperparathyroidism | 
                            O00255
                            (related)
                             | 
                        
| H01102 | Pituitary adenomas | 
                            O00255
                            (related)
                             | 
                        
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | 
                            P04150
                            (related)
                             | 
                        
| H00036 | Osteosarcoma | 
                            P08684
                            (marker)
                             | 
                        
| H00058 | Amyotrophic lateral sclerosis (ALS) | 
                            P10636
                            (related)
                             | 
                        
| H00077 | Progressive supranuclear palsy (PSP) | 
                            P10636
                            (related)
                             | 
                        
| H00078 | Frontotemporal lobar degeneration (FTLD) | 
                            P10636
                            (related)
                             | 
                        
| H00342 | Tuberculosis | 
                            P11473
                            (related)
                             | 
                        
| H00784 | Localized autosomal recessive hypotrichosis | 
                            P11473
                            (related)
                             | 
                        
| H01143 | Vitamin D-dependent rickets | 
                            P11473
                            (related)
                             | 
                        
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | 
                            P16473
                            (related)
                             | 
                        
| H01269 | Congenital hyperthyroidism | 
                            P16473
                            (related)
                             | 
                        
| H00027 | Ovarian cancer | 
                            P38398
                            (related)
                             | 
                        
| H00031 | Breast cancer | 
                            P38398
                            (related)
                             | 
                        
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | 
                            Q03164
                            (related)
                             Q03164 (marker)  | 
                        
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | 
                            Q03164
                            (related)
                             | 
                        
| H00063 | Spinocerebellar ataxia (SCA) | 
                            Q9NUW8
                            (related)
                             |