Species

KNApSAcK Entry

Organism name Merrillia caloxylon
Genus Merrillia
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Merrillia caloxylon
Linked NCBI taxonomy ID 159055
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003919 External link 512 Prosogerin E
No. 3 No. 15
C00003918 External link 512 5,7,3',4',5'-Pentamethoxyflavone
/ Tricetin 5,7,3',4',5'-pentamethyl ether
/ 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL2074901
1 / 1 / 0 No. 8 No. 15
C00003898 External link 512 5-Hydroxy-6,7,3',4'-tetramethoxyflavone
/ 6-Hydroxyluteolin 6,7,3',4'-tetramethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL226508
C045324
No. 8 No. 15
C00003871 External link 512 5,7,3',4'-Tetramethoxyflavone
/ Luteolin 5,7,3',4'-tetramethyl ether
CHEMBL327340
C103111
1 / 0 No. 8 No. 15
C00003949 External link 512 Umuhengerin
/ 5-Hydroxy-6,7,3',4',5'-pentamethoxyflavone
/ 5-Hydroxy-6,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL485823
C057913
No. 8 No. 15
C00006976 External link 512 3,2'-Dihydroxy-4,4',6'-trimethoxychalcone
CHEMBL571087
15 / 19 / 52 No. 79
C00006977 External link 512 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone
CHEMBL243830
3 / 3 / 0 No. 79
C00006988 External link 512 2'-Hydroxy-3,4,5,4',6'-pentamethoxychalcone
CHEMBL571877
1 / 2 / 0 No. 79
C00019945 External link 512 Merrillin
No. 1039

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00006977 C00006988 2 / 0
P08183 Multidrug resistance protein 1 drug C00003918 C00006977 1 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00006977 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00006976 7 / 37
P11473 Vitamin D3 receptor NR1I1 C00006976 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00006976 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00006976 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00006976 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00006976 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00006976 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00006976 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00006976 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00006976 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00006976 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00006976 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00006976 1 / 1
O00255 Menin Unclassified protein C00006976 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006976 1 / 2

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00003871

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (52)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)