Species

KNApSAcK Entry

Organism name Wyethia helenioides
Genus Wyethia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Wyethia helenioides
Linked NCBI taxonomy ID 230219
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005162 External link 512 Kaempferol 3-vicianoside
No. 1 No. 15
C00003885 External link 512 Nepetin
/ Eupafolin
/ 6-Methoxyluteolin
CHEMBL172350
31 / 34 / 60 No. 3 No. 15
C00009459 External link 512 Santal
/ 5,3',4'-Trihydroxy-7-methoxyisoflavone
No. 3 No. 15
C00009458 External link 512 3'-Methylorobol
/ 3'-O-Methylorobol
/ Orobol 3'-methyl ether
CHEMBL241402
No. 3 No. 15
C00008245 External link 512 8-Prenylnaringenin
/ Sophoraflavanone B
/ (-)-8-Prenylnaringenin
CHEMBL376915
CHEMBL460647
10 / 8 / 4 No. 28 No. 14
C00022037 External link 512 Wyethic acid
No. 945
C00011687 External link 512 Curcuquinone
/ Deoxyperezone
/ Desoxyperezone
/ (-)-Curcuquinone
/ (S)-(-)-Curcuquinone
No. 2612

Human Protein / Gene in interactions

38 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00003885 C00008245 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003885 C00008245 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003885 C00008245 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00003885 0 / 0
P04062 Glucosylceramidase Enzyme C00003885 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00003885 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00003885 7 / 37
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme C00003885 1 / 0
P37840 Alpha-synuclein Unclassified protein C00008245 4 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00003885 3 / 1
P54132 Bloom syndrome protein Enzyme C00003885 1 / 2
P11473 Vitamin D3 receptor NR1I1 C00003885 2 / 3
P39748 Flap endonuclease 1 Enzyme C00003885 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003885 2 / 0
O75496 Geminin Unclassified protein C00008245 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00008245 0 / 1
Q99700 Ataxin-2 Unclassified protein C00003885 1 / 1
Q9Y253 DNA polymerase eta Enzyme C00003885 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003885 0 / 0
P06746 DNA polymerase beta Enzyme C00003885 0 / 0
P04745 Alpha-amylase 1 Enzyme C00003885 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00008245 2 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003885 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003885 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00008245 0 / 0
P03372 Estrogen receptor NR3A1 C00008245 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00003885 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00003885 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003885 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003885 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00003885 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00003885 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003885 0 / 0
O00255 Menin Unclassified protein C00003885 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003885 1 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003885 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00003885 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00008245 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (41)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#114500 Colorectal cancer; crc P84022
Q14191
#127750 Dementia, lewy body; dlb P37840
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (61)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)