Seseli tortuosum LBS.Eur.

• Index
• Plant Species
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Seseli tortuosum LBS.Eur.
Genus	Seseli
Family	Apiaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Seseli
Linked NCBI taxonomy ID	40951
Linked level	genus

Family

Family in NCBI taxonomy	Apiaceae
ID	4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00002477	Imperatorin	CHEMBL453805	C031534	18 / 7 / 6	1 / 1	No. 606	No. 25
C00007558	Syringaldehyde / 4-Hydroxy-3,5-dimethoxybenzaldehyde	CHEMBL225303	C069665			No. 856
C00000575	Bergaptan	CHEMBL24171	C022909	22 / 22 / 17	0 / 3	No. 1282	No. 25
C00000576	Xanthotoxin	CHEMBL416	D008730	104 / 55 / 45	22 / 18	No. 1282	No. 25
C00002466	Decursinol	CHEMBL481657		4 / 3 / 0		No. 1336	No. 25
C00029297	Columbianetin / (+)-Columbianetin	CHEMBL201152		7 / 12 / 8		No. 1336	No. 25

Human Protein / Gene in interactions

137 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P56817	Beta-secretase 1	A1A	C00000575 C00000576 C00002466 C00002477 C00029297	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000575 C00000576 C00002477 C00003672	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000575 C00000576 C00003672	1 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000575 C00000576 C00002477	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000575 C00000576 C00003672	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000575 C00000576 C00003672	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00000575 C00002477 C00029297	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00000575 C00000576 C00029297	7 / 3
P16473	Thyrotropin receptor	Glycohormone receptor	C00000575 C00000576 C00003672	3 / 2
P10275	Androgen receptor	NR3C4	C00000575 C00000576	3 / 4
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000576 C00003672	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000575 C00029297	0 / 0
P03372	Estrogen receptor	NR3A1	C00000576 C00003672	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00000576 C00002466	1 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00000576 C00002477	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000575 C00000576	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002477 C00029297	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002477 C00003672	2 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000576 C00002477	2 / 3
Q09470	Potassium voltage-gated channel subfamily A member 1	KCNA, Kv1.x (Shaker)	C00000575 C00000576	1 / 1
P08183	Multidrug resistance protein 1	drug	C00000575 C00003672	1 / 0
P20813	Cytochrome P450 2B6	Cytochrome P450 2B6	C00000575 C00000576	1 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00000576 C00002477	1 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00003672	0 / 0
P17658	Potassium voltage-gated channel subfamily A member 6	K	C00000575	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000576	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000576	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000576	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000576	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000576	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000576	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000576	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000576	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000576	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00002477	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00002477	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000576	2 / 2
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000576	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000576	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000576	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000576	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00000576	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000576	1 / 8
P17252	Protein kinase C alpha type	Alpha	C00000576	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00000576	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000576	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000576	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000576	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000576	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000576	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000576	0 / 0
P16389	Potassium voltage-gated channel subfamily A member 2	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000576	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000576	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000576	1 / 0
P29466	Caspase-1	C14	C00000576	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00029297	2 / 2
P22001	Potassium voltage-gated channel subfamily A member 3	KCNA, Kv1.x (Shaker)	C00000575	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002466	2 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000576	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000576	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000576	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000576	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000576	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000576	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000576	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000576	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000576	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000576	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000576	1 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672	0 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000576	0 / 0
P08311	Cathepsin G	S1A	C00000576	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000576	1 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000576	0 / 0
P03956	Interstitial collagenase	M10A	C00000576	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000576	0 / 0
P06746	DNA polymerase beta	Enzyme	C00003672	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000576	0 / 0
Q9NPD5	Solute carrier organic anion transporter family member 1B3	Electrochemical transporter	C00000576	1 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002477	0 / 0
P00734	Prothrombin	S1A	C00003672	4 / 2
P04150	Glucocorticoid receptor	NR3C1	C00000576	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000576	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000576	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00003672	4 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000576	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000576	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000576	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000576	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000576	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000576	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000576	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000576	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00002477	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000576	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000576	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000576	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00000576	0 / 0
P08246	Neutrophil elastase	S1A	C00000576	2 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000575	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00029297	2 / 2
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000576	2 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002466	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000576	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000576	0 / 3
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000576	1 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000576	0 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000576	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000576	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000576	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000576	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000576	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000576	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000576	0 / 0
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00000576	0 / 0
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	Electrochemical transporter	C00000576	1 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000576	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002477	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002477	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000575	0 / 0
P48547	Potassium voltage-gated channel subfamily C member 1	K	C00000575	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000576	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000576	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000576	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000576	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000576	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000576	0 / 1
P22460	Potassium voltage-gated channel subfamily A member 5	KCNA, Kv1.x (Shaker)	C00000575	1 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000576	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672	0 / 0
O00167	Eyes absent homolog 2	Enzyme	C00002477	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002477	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003672	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002477	1 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000576	0 / 0

23 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00002477
581	BAX, BCL2L4	BCL2-associated X protein	C00000576
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000576
8553	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14	basic helix-loop-helix family, member e40	C00000576
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00000576
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000576
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000576
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00000576
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00000576
8824	CES2, CE-2, CES2A1, PCE-2, iCE	carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56)	C00000576
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000576
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00000576
1553	CYP2A13, CPAD, CYP2A, CYPIIA13	cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1)	C00000576
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00000576
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00000576
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00000576
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000576
3034	HAL, HIS, HSTD	histidine ammonia-lyase (EC:4.3.1.3)	C00000576
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00000576
3355109			C00000576
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000576
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000576
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000576

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions