PCIDB

KNApSAcK Metabolite C00000576

Metabolite

KNApSAcK Entry

id C00000576
Name Xanthotoxin
CAS RN 298-81-7
Standard InChI InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
Standard InChI (Main Layer) InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

Cluster

Phytochemical cluster No. 25
KCF-S cluster No. 1282

Link

ChEMBL

By standard InChI CHEMBL416
By standard InChI Main Layer CHEMBL416

KEGG

By LinkDB C01864

CTD

By CAS RN D008730

Species

Summary

Plant class

class name count
asterids 29
rosids 11

Family

family name count
Apiaceae 29
Rutaceae 8
Fabaceae 3

List (40)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ammi majus 48026 Apiaceae asterids Viridiplantae
Angelica archangelica 40949 Apiaceae asterids Viridiplantae
Angelica gigas 85712 Apiaceae asterids Viridiplantae
Angelica keiskei 357850 Apiaceae asterids Viridiplantae
Angelica officinalis 40948 Apiaceae asterids Viridiplantae
Angelica ursina Maxim 40948 Apiaceae asterids Viridiplantae
Apium graveolens 4045 Apiaceae asterids Viridiplantae
Atalantia ceylanica 76951 Rutaceae rosids Viridiplantae
Bituminaria bituminosa 53836 Fabaceae rosids Viridiplantae
Caragana frutex 47643 Fabaceae rosids Viridiplantae
Clausena anisata 159034 Rutaceae rosids Viridiplantae
Cnidium monnieri 94007 Apiaceae asterids Viridiplantae
Dictamnus hispanicus 77005 Rutaceae rosids Viridiplantae
Fagara mayu 23513 Rutaceae rosids Viridiplantae
Fagara spp. 23513 Rutaceae rosids Viridiplantae
Feronia limonia 159053 Rutaceae rosids Viridiplantae
Ferula sumbul 371383 Apiaceae asterids Viridiplantae
Heracleum asperum 380072 Apiaceae asterids Viridiplantae
Heracleum canescens 376873 Apiaceae asterids Viridiplantae
Heracleum granatense 40917 Apiaceae asterids Viridiplantae
Heracleum grandiflorum 380075 Apiaceae asterids Viridiplantae
Heracleum lanatum 40918 Apiaceae asterids Viridiplantae
Heracleum moellendorffii Hance 99507 Apiaceae asterids Viridiplantae
Heracleum moellendorffii Hance var.paucivitatum 40917 Apiaceae asterids Viridiplantae
Heracleum pinnatum 376875 Apiaceae asterids Viridiplantae
Heracleum ponticum 376867 Apiaceae asterids Viridiplantae
Heracleum sphondylium 40919 Apiaceae asterids Viridiplantae
Heracleum woroschiklowii 40917 Apiaceae asterids Viridiplantae
Leptothyrsa sprucei 23513 Rutaceae rosids Viridiplantae
Ligusticum multivittatum 49551 Apiaceae asterids Viridiplantae
Niphogeton ternata 681593 Apiaceae asterids Viridiplantae
Pastinaca sativa 4041 Apiaceae asterids Viridiplantae
Petroselinum crispum 4043 Apiaceae asterids Viridiplantae
Prangos tschimganica 52496 Apiaceae asterids Viridiplantae
Ruta spp. 37564 Rutaceae rosids Viridiplantae
Saposhnikovia divaricata Schischkin 203716 Apiaceae asterids Viridiplantae
Seseli tortuosum LBS.Eur. 40951 Apiaceae asterids Viridiplantae
Seseli webbii Cosson. 40951 Apiaceae asterids Viridiplantae
Tordylium apulum 489417 Apiaceae asterids Viridiplantae
Vicia sativa 3908 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

104 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL416 CHEMBL1614110 (1) CHEMBL1741321 (1)
CHEMBL1909136 (2)
1 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) CHEMBL416 CHEMBL703981 (1) CHEMBL703982 (1)
1 / 1
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL416 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL416 CHEMBL2169431 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL416 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL416 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL416 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL416 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL416 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL416 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL416 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL416 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL416 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL416 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL416 CHEMBL1909197 (2)
2 / 2
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 CHEMBL416 CHEMBL1743495 (1) CHEMBL1743496 (1)
1 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL416 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL416 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL416 CHEMBL865201 (1) CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL416 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL416 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL416 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL416 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL416 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL416 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL416 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL416 CHEMBL1741325 (1) CHEMBL1909135 (2)
0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL416 CHEMBL934455 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL416 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL416 CHEMBL1794339 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL416 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL416 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL416 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL416 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL416 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL416 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL416 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL416 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL416 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL416 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL416 CHEMBL1743275 (1) CHEMBL1743499 (1)
CHEMBL1743536 (1) CHEMBL1743539 (2)
CHEMBL1743540 (2) CHEMBL1743368 (2)
CHEMBL1909133 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL416 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL416 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL416 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL416 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL416 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL416 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL416 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL416 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL416 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL416 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL416 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL416 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL416 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL416 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL416 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL416 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL416 CHEMBL2114810 (1)
7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL416 CHEMBL1794401 (1)
0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL416 CHEMBL2169430 (1)
1 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL416 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL416 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL416 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL416 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL416 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL416 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL416 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL416 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL416 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL416 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL416 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL416 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL416 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL416 CHEMBL1909207 (2)
2 / 1
P56817 Beta-secretase 1 A1A CHEMBL416 CHEMBL1936881 (1) CHEMBL1936882 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL416 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL416 CHEMBL2114842 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL416 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL416 CHEMBL1794364 (1) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL416 CHEMBL1003053 (1) CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL416 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL416 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL416 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL416 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL416 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL416 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL416 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL416 CHEMBL1613777 (1) CHEMBL1741323 (1)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL416 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL416 CHEMBL1909137 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL416 CHEMBL1794560 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL416 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL416 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL416 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL416 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL416 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL416 CHEMBL1909128 (2)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL416 CHEMBL2354287 (1)
1 / 1

CTD interaction (41)

compound gene gene name gene description interaction interaction type form reference
pmid
D008730 581 BAX
BCL2L4
BCL2-associated X protein Methoxsalen results in increased expression of BAX protein increases expression
protein 22796345
D008730 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Methoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 22743290
D008730 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Methoxsalen results in decreased expression of BCL2 protein decreases expression
protein 22796345
D008730 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] decreases expression
/ decreases reaction
protein 22796345
D008730 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein] decreases expression
/ decreases reaction
/ increases activity
protein 22796345
D008730 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 BHLHE40 protein results in decreased susceptibility to Methoxsalen decreases response to substance
protein 22796345
D008730 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 Methoxsalen results in decreased expression of BHLHE40 mRNA decreases expression
mRNA 22796345
D008730 8553 BHLHE40
BHLHB2
DEC1
HLHB2
SHARP-2
STRA13
Stra14
basic helix-loop-helix family, member e40 Methoxsalen results in decreased expression of BHLHE40 protein decreases expression
protein 22796345
D008730 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] decreases expression
/ decreases reaction
protein 22796345
D008730 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Methoxsalen results in decreased expression of BIRC5 protein decreases expression
protein 22796345
D008730 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein] decreases expression
/ decreases reaction
/ increases activity
protein 22796345
D008730 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 22743290
D008730 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Methoxsalen results in decreased expression of and results in increased activity of CASP3 protein decreases expression
/ increases activity
protein 22796345
D008730 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Methoxsalen results in decreased expression of CASP8 protein decreases expression
protein 22796345
D008730 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Methoxsalen results in decreased expression of CASP9 protein decreases expression
protein 22796345
D008730 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] decreases reaction
/ increases expression
protein 15157999
D008730 8824 CES2
CE-2
CES2A1
PCE-2
iCE
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA] decreases reaction
/ increases expression
mRNA 17003103
D008730 8824 CES2
CE-2
CES2A1
PCE-2
iCE
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) Methoxsalen results in increased expression of CES2 mRNA increases expression
mRNA 17003103
D008730 8824 CES2
CE-2
CES2A1
PCE-2
iCE
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) Methoxsalen results in increased expression of CES2 protein increases expression
protein 17003103
D008730 8824 CES2
CE-2
CES2A1
PCE-2
iCE
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA] increases expression
/ increases reaction
mRNA 17003103
D008730 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 9169082
D008730 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Methoxsalen results in decreased activity of CYP1A2 protein decreases activity
protein 8819299
D008730 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] decreases reaction
/ increases activity
/ increases metabolic processing
protein 17671098
D008730 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) Methoxsalen inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1] decreases reaction
/ increases response to substance
protein 22743290
D008730 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) [Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole decreases activity
/ decreases response to substance
protein 20795680
D008730 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) Methoxsalen results in decreased activity of CYP2A6 protein decreases activity
protein 8819299
10911933
11353760
12464242
12814958
15306208
15893417
18813816
D008730 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) Methoxsalen results in decreased activity of CYP2C9 protein decreases activity
protein 18420780
D008730 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) Methoxsalen results in decreased activity of CYP2D6 protein decreases activity
protein 18420780
D008730 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] decreases reaction
/ increases expression
mRNA 17003103
D008730 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Methoxsalen results in decreased activity of CYP3A4 protein decreases activity
protein 18420780
D008730 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Methoxsalen results in increased expression of CYP3A4 mRNA increases expression
mRNA 17003103
D008730 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Methoxsalen results in increased expression of CYP3A4 protein increases expression
protein 17003103
D008730 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] increases expression
/ increases reaction
mRNA 17003103
D008730 3034 HAL
HIS
HSTD
histidine ammonia-lyase (EC:4.3.1.3) Methoxsalen results in decreased activity of HAL protein decreases activity
protein 20880231
D008730 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 Methoxsalen results in increased activity of NR1I2 protein increases activity
protein 17003103
D008730 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA] increases expression
/ increases reaction
protein 17003103
D008730 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] increases expression
/ increases reaction
protein 17003103
D008730 3355109 Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP protein modified form] decreases reaction
/ increases expression
protein 22743290
D008730 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] decreases phosphorylation
/ decreases reaction
protein 15157999
D008730 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Methoxsalen analog results in decreased expression of TNF protein decreases expression
protein 15052360
D008730 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Methoxsalen results in increased expression of TP53 protein increases expression
protein 22796345

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (55)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#160120 Episodic ataxia, type 1; ea1 Q09470
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (45)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00749 Episodic ataxias Q09470 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

18 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D008730 Abdominal Pain marker/mechanism
8784281
D056486 D008730 Drug-Induced Liver Injury marker/mechanism
22173200
D004485 D008730 Eczema therapeutic
16259964
D006261 D008730 Headache marker/mechanism
8784281
D007674 D008730 Kidney Diseases therapeutic
2344991
D017114 D008730 Liver Failure, Acute marker/mechanism
8308218
D008175 D008730 Lung Neoplasms therapeutic
15893417
D016410 D008730 Lymphoma, T-Cell, Cutaneous therapeutic
17003103
D008881 D008730 Migraine Disorders marker/mechanism
16869874
D009182 D008730 Mycosis Fungoides therapeutic
16259964
D009325 D008730 Nausea marker/mechanism
8784281
D000857 D008730 Olfaction Disorders marker/mechanism
12925193
16869874
D011565 D008730 Psoriasis therapeutic
8308218
8784281
12925193
14571091
16259964
17003103
D011693 D008730 Purpura marker/mechanism
7232190
D007319 D008730 Sleep Initiation and Maintenance Disorders marker/mechanism
14571091
D014006 D008730 Tinea Capitis therapeutic
14571091
D015837 D008730 Vestibular Diseases therapeutic
18990727
D014820 D008730 Vitiligo therapeutic
16259964