PCIDB

Angelica archangelica

Species

KNApSAcK Entry

Organism name Angelica archangelica
Genus Angelica
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Angelica archangelica
Linked NCBI taxonomy ID 40949
Linked level species

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (27)

Species Activity
Angelica archangelica L. Abortifacient
Angelica archangelica L. Antibacterial
Angelica archangelica L. Antiedemic
Angelica archangelica L. Antiinflammatory
Angelica archangelica L. Antispasmodic
Angelica archangelica L. Aperitif
Angelica archangelica L. Bitter
Angelica archangelica L. Calcium Antagonist
Angelica archangelica L. Carminative
Angelica archangelica L. Cholagogue
Angelica archangelica L. Cytostatic
Angelica archangelica L. Diaphoretic
Angelica archangelica L. Digestive
Angelica archangelica L. Diuretic
Angelica archangelica L. Emmenagogue
Angelica archangelica L. Expectorant
Angelica archangelica L. Fungicide
Angelica archangelica L. Gastrogogue
Angelica archangelica L. Myorelaxant
Angelica archangelica L. Photocarcinogenic
Angelica archangelica L. phototoxic
Angelica archangelica L. Rubefacient
Angelica archangelica L. Secretagogue
Angelica archangelica L. Stimulant
Angelica archangelica L. Stomachic
Angelica archangelica L. Tonic
Angelica archangelica L. Tracheorelaxant

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003750 External link 512 Lupeol acetate
CHEMBL453802
CHEMBL1097034
C055329
1 / 0 / 0 No. 23 No. 51
C00003737 External link 512 alpha-Amyrin
/ alpha-Amyrine
/ alpha-Amyrenol
No. 23 No. 51
C00002451 External link 512 Archangelicin
CHEMBL1426896
17 / 18 / 10 No. 224 No. 25
C00021868 External link 512 alpha-Copaen-8-ol
No. 333 No. 38
C00002488 External link 512 Osthol
/ Osthole
CHEMBL52229
C046627
12 / 6 / 5 7 / 4 No. 466 No. 25
C00030532 External link 512 Isoimperatorin
CHEMBL448060
C055542
8 / 13 / 11 3 / 1 No. 606 No. 25
C00002477 External link 512 Imperatorin
CHEMBL453805
C031534
18 / 7 / 6 1 / 1 No. 606 No. 25
C00000583 External link 512 Isopimpinellin
CHEMBL140796
C015304
9 / 3 / 4 2 / 0 No. 606 No. 25
C00000575 External link 512 Bergaptan
CHEMBL24171
C022909
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00002450 External link 512 Angelicin
CHEMBL53569
C011659
2 / 0 / 0 0 / 3 No. 1282 No. 25
C00000576 External link 512 Xanthotoxin
CHEMBL416
D008730
104 / 55 / 45 22 / 18 No. 1282 No. 25
C00000582 External link 512 Xanthotoxol
/ 8-Hydroxyanthotoxol
CHEMBL1192
C021768
2 / 2 / 2 No. 1282 No. 25
C00001153 External link 512 Umbelliferose
No. 1765
C00034737 External link 512 Umbelliprenin
CHEMBL156127
8 / 3 / 3 No. 2038
C00010952 External link 512 (4R-cis)-3-Methylene-6-(1-methylethyl)-4-nitrocyclohexene
No. 3416
C00010951 External link 512 (R)-Methyl-5-(1-methylethyl)-1-nitro-1,3-cyclohexadiene
No. 3416
C00010953 External link 512 (4S-trans)-3-Methylene-6-(1-methylethyl)-4-nitrocyclohexene
No. 3416
C00001207 External link 512 Tiglic acid
CHEMBL55941
CHEMBL52416
No. 5138
C00021926 External link 512 7-Isopropyl-5-methylbicyclo[2.2.2]oct-5-en-2-one
No. 7557

Human Protein / Gene in interactions

147 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00000575 C00000576 C00000582 C00000583 C00002450 C00002477 C00002488 C00030532 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00000576 C00002451 C00002477 C00002488 C00034737 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002451 C00002477 C00002488 C00030532 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 C00000576 C00000583 C00002477 C00002488 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000576 C00002451 C00002477 C00002488 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000576 C00000583 C00002477 C00030532 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 C00000583 C00002451 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 C00000583 C00002451 0 / 0
O75496 Geminin Unclassified protein C00002451 C00002488 C00034737 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 C00000576 C00002451 7 / 3
P06746 DNA polymerase beta Enzyme C00000583 C00002451 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 C00000576 1 / 1
P22303 Acetylcholinesterase Hydrolase C00000576 C00030532 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 C00000576 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000583 C00002451 2 / 2
Q9UNA4 DNA polymerase iota Enzyme C00030532 C00034737 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000576 C00002451 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002477 C00034737 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002477 C00002488 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000583 C00002477 0 / 0
P10275 Androgen receptor NR3C4 C00000575 C00000576 3 / 4
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002477 C00030532 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002451 C00002477 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 C00000576 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00000582 C00034737 2 / 2
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 C00000576 1 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 C00000576 1 / 1
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000576 C00002451 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000575 C00000576 3 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000576 C00002488 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000576 C00002477 2 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 C00000576 1 / 0
P25021 Histamine H2 receptor Histamine receptor C00000576 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000576 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000576 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000576 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000576 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000576 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00002477 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00002477 0 / 0
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000576 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000576 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000576 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000576 1 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 C00000576 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000576 1 / 8
P11388 DNA topoisomerase 2-alpha Isomerase C00003750 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000576 0 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00000576 2 / 0
P00918 Carbonic anhydrase 2 Lyase C00000576 1 / 2
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000576 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000576 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000576 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000576 0 / 0
P02545 Prelamin-A/C Unclassified protein C00030532 11 / 10
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000576 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000576 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000576 1 / 0
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000576 2 / 2
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002488 0 / 0
P39748 Flap endonuclease 1 Enzyme C00034737 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000583 0 / 0
P42858 Huntingtin Unclassified protein C00002451 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002451 2 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000576 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000576 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000576 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000576 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000576 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000576 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000576 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000576 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000576 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000576 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000576 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000576 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000576 0 / 0
P08311 Cathepsin G S1A C00000576 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000576 1 / 0
P17252 Protein kinase C alpha type Alpha C00000576 0 / 0
P03956 Interstitial collagenase M10A C00000576 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000576 0 / 0
P29466 Caspase-1 C14 C00000576 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002477 1 / 1
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000576 1 / 0
P04062 Glucosylceramidase Enzyme C00002488 6 / 4
P04150 Glucocorticoid receptor NR3C1 C00000576 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000576 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000576 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000576 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000576 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000576 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000576 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000576 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000576 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000576 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000576 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00002477 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000576 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000576 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000576 2 / 1
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000576 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 3 / 3
Q16539 Mitogen-activated protein kinase 14 p38 C00000576 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000576 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000576 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000576 0 / 0
P03372 Estrogen receptor NR3A1 C00000576 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000576 1 / 0
P08246 Neutrophil elastase S1A C00000576 2 / 1
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000576 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000576 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000576 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000576 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000576 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000576 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000576 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002450 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00034737 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000576 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000576 0 / 3
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000576 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000576 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002488 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002477 2 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002451 4 / 3
Q99700 Ataxin-2 Unclassified protein C00002451 1 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000576 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000576 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000576 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000576 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000576 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000576 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000576 0 / 1
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000576 0 / 0
O14980 Exportin-1 Unclassified protein C00002488 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00030532 0 / 0
O00167 Eyes absent homolog 2 Enzyme C00002477 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000576 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00034737 1 / 1
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002451 0 / 0

32 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000583 C00002477 C00030532
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000576 C00000583
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000576
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00002488
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002488
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00002488
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00002488
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002488
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002488
2939 GSTA2, GST2, GSTA2-2, GTA2, GTH2 glutathione S-transferase alpha 2 (EC:2.5.1.18) C00030532
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00030532
581 BAX, BCL2L4 BCL2-associated X protein C00000576
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000576
8553 BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14 basic helix-loop-helix family, member e40 C00000576
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00000576
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000576
2180 ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) C00002488
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000576
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000576
8824 CES2, CE-2, CES2A1, PCE-2, iCE carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) C00000576
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000576
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000576
1553 CYP2A13, CPAD, CYP2A, CYPIIA13 cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) C00000576
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00000576
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00000576
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00000576
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000576
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00000576
3355109 C00000576
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000576
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000576
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000576

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (93)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#160120 Episodic ataxia, type 1; ea1 Q09470
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (71)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00731 Atrial fibrillation P22460 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00749 Episodic ataxias Q09470 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

25 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002450
C00002477
C00030532
C00000576
D011565 Psoriasis C00000575
C00000576
D010787 Photosensitivity Disorders C00002450
C00000575
D007674 Kidney Diseases C00000576
D000647 Amnesia C00002450
C538231 Adenocarcinoma of lung C00002488
D003920 Diabetes Mellitus C00002488
D006943 Hyperglycemia C00002488
D009361 Neoplasm Invasiveness C00002488
D015746 Abdominal Pain C00000576
D004485 Eczema C00000576
D006261 Headache C00000576
D006505 Hepatitis C00000575
D017114 Liver Failure, Acute C00000576
D008175 Lung Neoplasms C00000576
D016410 Lymphoma, T-Cell, Cutaneous C00000576
D008881 Migraine Disorders C00000576
D009182 Mycosis Fungoides C00000576
D009325 Nausea C00000576
D000857 Olfaction Disorders C00000576
D011693 Purpura C00000576
D007319 Sleep Initiation and Maintenance Disorders C00000576
D014006 Tinea Capitis C00000576
D015837 Vestibular Diseases C00000576
D014820 Vitiligo C00000576