Species

KNApSAcK Entry

Organism name Millettia leucantha
Genus Millettia
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Millettia
Linked NCBI taxonomy ID 53625
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003997 External link 512 Milleyanaflavone
/ 7-Methoxy-3',4'-methylenedioxyflavone
/ 2-(1,3-Benzodioxol-5-yl)-7-methoxy-4H-1-benzopyran-4-one
No. 27 No. 15
C00005045 External link 512 Demethoxykanugin
/ 2-(1,3-Benzodioxol-5-yl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL2205108
No. 27 No. 15
C00013398 External link 512 3',4'-Methylenedioxy-5,7-dimethoxyflavone
/ 5,7-Dimethoxy-3',4'-methylenedioxyflavone
/ 2-(1,3-Benzodioxol-5-yl)-5,7-dimethoxy-4H-1-benzopyran-4-one
No. 27 No. 15
C00013397 External link 512 5-Hydroxy-7-methoxy-3',4'-methylenedioxyflavone
/ 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
No. 27 No. 15
C00005089 External link 512 Karanjin
/ 3-Methoxy-2-phenyl-4H-Furo[2,3-h]-1-benzopyran-4-one
CHEMBL208484
C052068
20 / 21 / 18 No. 35 No. 15
C00006977 External link 512 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone
CHEMBL243830
3 / 3 / 0 No. 79
C00009741 External link 512 Claussequinone
/ 7-Hydroxy-4'-methoxyisoflavanquinone
CHEMBL446542
C088068
No. 517
C00009742 External link 512 Pendulone
/ 7-Hydroxy-3',4'-dimethoxyisoflavanquinone
No. 517
C00014439 External link 512 3',4'-Methylenedioxy-2,4,6,beta-tetramethoxychalcone
No. 676
C00014431 External link 512 3,4-Methylenedioxy-2',4',6'-trimethoxychalcone
CHEMBL404603
No. 676
C00007958 External link 512 Dihydromilletenone methyl ether
No. 882
C00014608 External link 512 2',4',6'-Trimethoxy-3,4-methylenedioxydihydrochalcone
No. 882

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00005089 1 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00006977 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00005089 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005089 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00005089 3 / 2
P08183 Multidrug resistance protein 1 drug C00006977 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00005089 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00005089 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005089 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00005089 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00005089 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005089 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005089 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00006977 2 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00005089 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005089 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00005089 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005089 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00005089 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00005089 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005089 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005089 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005089 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614490 Blood group, junior system; jr Q9UNQ0
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (18)

KEGG name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)