KNApSAcK Entry

Organism name Angelica dahurica var.dahurica
Genus Angelica
Family Apiaceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Angelica
Linked NCBI taxonomy ID 40948
Linked level genus


Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00035717 External link 512 (+)-Oxypeucedanin
/ Oxypeucedanin hydrate
13 / 5 / 8 No. 579 No. 25
C00002453 External link 512 Byakangelicin
/ (+)-Byakangelicin
5 / 2 / 0 No. 579 No. 25
C00030987 External link 512 Phellopterin
7 / 18 / 10 No. 606 No. 25
C00000575 External link 512 Bergaptan
22 / 22 / 17 0 / 3 No. 1282 No. 25
C00002490 External link 512 Oxypeucedanin
8 / 14 / 11 No. 2896 No. 25

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P56817 Beta-secretase 1 A1A C00000575 C00002453 C00002490 C00030987 C00035717 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000575 C00002453 C00002490 C00035717 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000575 C00002453 0 / 0
P06746 DNA polymerase beta Enzyme C00002490 C00035717 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00030987 C00035717 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002453 C00030987 1 / 0
O75496 Geminin Unclassified protein C00002490 C00035717 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000575 C00002490 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000575 C00030987 7 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00000575 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00002490 3 / 1
P08183 Multidrug resistance protein 1 drug C00000575 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000575 0 / 1
P37840 Alpha-synuclein Unclassified protein C00030987 4 / 2
P16389 Potassium voltage-gated channel subfamily A member 2 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002490 11 / 10
P17405 Sphingomyelin phosphodiesterase Enzyme C00035717 2 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000575 0 / 0
P11413 Glucose-6-phosphate 1-dehydrogenase Enzyme C00030987 1 / 2
P17658 Potassium voltage-gated channel subfamily A member 6 K C00000575 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00000575 1 / 0
Q9Y253 DNA polymerase eta Enzyme C00035717 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00035717 0 / 0
P22001 Potassium voltage-gated channel subfamily A member 3 KCNA, Kv1.x (Shaker) C00000575 0 / 0
P48547 Potassium voltage-gated channel subfamily C member 1 K C00000575 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000575 3 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000575 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000575 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00035717 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00035717 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00030987 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000575 0 / 0
P10275 Androgen receptor NR3C4 C00000575 3 / 4
P22460 Potassium voltage-gated channel subfamily A member 5 KCNA, Kv1.x (Shaker) C00000575 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00035717 0 / 0
Q09470 Potassium voltage-gated channel subfamily A member 1 KCNA, Kv1.x (Shaker) C00000575 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002490 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002453 1 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00035717 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00035717 1 / 4
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000575 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#300908 Anemia, nonspherocytic hemolytic, due to g6pd deficiency P11413
#612240 Atrial fibrillation, familial, 7; atfb7 P22460
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#614546 Efavirenz, poor metabolism of P20813
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#160120 Episodic ataxia, type 1; ea1 Q09470
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253


KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00101 Other phagocyte defects P11413 (related)
H00668 Anemia due to disorders of glutathione metabolism P11413 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00731 Atrial fibrillation P22460 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00749 Episodic ataxias Q09470 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

D006505 Hepatitis C00000575
D010787 Photosensitivity Disorders C00000575
D011565 Psoriasis C00000575