Species

KNApSAcK Entry

Organism name Siegesbeckia orientalis
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Sigesbeckia orientalis
Linked NCBI taxonomy ID 185191
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004638 External link 512 Quercetin 3,7-dimethyl ether
/ 5,3',4'-Trihydroxy-3,7-dimethoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL164861
C065497
2 / 1 / 2 No. 3 No. 15
C00004647 External link 512 Ayanin
/ 3,7,4'-Tri-O-methylquercetin
/ 5,3'-Dihydroxy-3,7,4'-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL74898
18 / 10 / 2 No. 3 No. 15
C00004653 External link 512 Retusine
/ Retusin(Ariocarpus)
/ Quercetin 3,7,3',4'-tetramethyl ether
/ 5-Hydroxy-3,7,3',4'-tetramethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL77966
3 / 3 / 0 No. 8 No. 15
C00012233 External link 512 Orientalide
No. 60 No. 38
C00012299 External link 512 Arcotiopicrin
/ Orientin (sesquiterpene)
No. 1445 No. 38

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33527 Multidrug resistance-associated protein 1 drugs C00004647 C00004653 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004647 C00004653 2 / 0
P08183 Multidrug resistance protein 1 drug C00004647 C00004653 1 / 0
P07437 Tubulin beta chain Structural C00004647 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004638 0 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004647 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004647 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004647 1 / 0
P04350 Tubulin beta-4A chain Structural C00004647 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004647 0 / 0
P00747 Plasminogen S1A C00004638 1 / 2
Q71U36 Tubulin alpha-1A chain Structural C00004647 1 / 1
P68371 Tubulin beta-4B chain Structural C00004647 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004647 2 / 1
P68363 Tubulin alpha-1B chain Unclassified protein C00004647 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004647 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004647 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004647 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004647 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004647 1 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#614490 Blood group, junior system; jr Q9UNQ0
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#612244 Inflammatory bowel disease 13; ibd13 P08183
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#217090 Plasminogen deficiency, type i P00747
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (4)

KEGG name UniProt
H00223 Inherited thrombophilia P00747 (related)
H01206 Plasminogen deficiency P00747 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)