PCIDB

Gutierrezia grandis

Species

KNApSAcK Entry

Organism name Gutierrezia grandis
Genus Gutierrezia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Gutierrezia
Linked NCBI taxonomy ID 71047
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (18)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005797 External link 512 5,7,3',5'-Tetrahydroxy-3,6,8,4'-tetramethoxyflavone 3'-glucoside
No. 2 No. 15
C00005382 External link 512 Quercimeritrin
/ Quercetin 7-glucoside
/ Quercetin 7-O-beta-D-glucoside
CHEMBL248726
C089996
No. 2 No. 15
C00005524 External link 512 Isorhamnetin 3-galactoside
CHEMBL234316
CHEMBL516621
1 / 1 / 0 No. 2 No. 15
C00005372 External link 512 Hyperin
/ Hyperoside
/ Quercetin 3-O-galactoside
/ Quercetin 3-O-beta-D-galactoside
/ Quercetin 3-beta-galactopyranoside
/ Quercetin 3-O-beta-D-galactopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
C021304
38 / 43 / 34 4 / 0 No. 2 No. 15
C00004808 External link 512 5,7,2',5'-Tetrahydroxy-3,6,4'-trimethoxyflavone
No. 3 No. 15
C00004823 External link 512 5,7,3',5'-Tetrahydroxy-3,6,4'-trimethoxyflavone
No. 3 No. 15
C00004843 External link 512 Hibiscetin 3,8,4'-trimethyl ether
No. 3 No. 15
C00004788 External link 512 3,5,7,3',4'-Pentahydroxy-6,8-dimethoxyflavone
No. 3 No. 15
C00004809 External link 512 5,7,2',4'-Tetrahydroxy-3,6,5'-trimethoxyflavone
No. 3 No. 15
C00004764 External link 512 Myricetin 3,4'-dimethyl ether
CHEMBL1689268
1 / 1 / 0 No. 3 No. 15
C00004859 External link 512 5,7,3',5'-Tetrahydroxy-3,6,8,4'-tetramethoxyflavone
No. 8 No. 15
C00004863 External link 512 5,7,4'-Trihydroxy-3,6,8,3',5'-pentamethoxyflavone
No. 8 No. 15
C00004864 External link 512 5,7,3'-Trihydroxy-3,6,8,4',5'-pentamethoxyflavone
CHEMBL74923
No. 8 No. 15
C00004868 External link 512 5,7-Dihydroxy-3,6,8,3',4',5'-hexamethoxyflavone
/ 5,7-Dihydroxy-3,6,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL77385
15 / 7 / 2 No. 8 No. 15
C00004851 External link 512 5,7,2',4'-Tetrahydroxy-3,6,8,5'-tetramethoxyflavone
No. 8 No. 15
C00004850 External link 512 5,7,2',5'-Tetrahydroxy-3,6,8,4'-tetramethoxyflavone
No. 8 No. 15
C00004795 External link 512 5,7,3'-Trihydroxy-3,6,8,4'-tetramethoxyflavone
CHEMBL1094282
No. 8 No. 15
C00004858 External link 512 5,7,3',4',5'-Pentahydroxy-3,6,8-trimethoxyflavone
No. 8 No. 15

Human Protein / Gene in interactions

54 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005372 C00005524 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005372 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005372 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005372 0 / 3
P06746 DNA polymerase beta Enzyme C00005372 0 / 0
P04062 Glucosylceramidase Enzyme C00005372 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00005372 1 / 1
P02545 Prelamin-A/C Unclassified protein C00005372 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005372 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005372 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005372 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005372 1 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005372 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005372 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005372 0 / 0
O75496 Geminin Unclassified protein C00005372 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005372 0 / 0
P15121 Aldose reductase Enzyme C00005372 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005372 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005372 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005372 3 / 1
P14679 Tyrosinase Oxidoreductase C00005372 4 / 2
P06280 Alpha-galactosidase A Enzyme C00005372 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005372 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005372 0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005372 2 / 0
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00004764 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005372 4 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005372 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005372 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005372 4 / 3
Q9NPH5 NADPH oxidase 4 Enzyme C00005372 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005372 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005372 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005372 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005372 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005372 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005372 1 / 4
Q13748 Tubulin alpha-3C/D chain Structural C00004868 0 / 0
P68366 Tubulin alpha-4A chain Structural C00004868 0 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004868 1 / 0
P04350 Tubulin beta-4A chain Structural C00004868 2 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004868 0 / 0
P07437 Tubulin beta chain Structural C00004868 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004868 1 / 1
P68371 Tubulin beta-4B chain Structural C00004868 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004868 2 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005372 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00004868 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004868 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004868 0 / 0
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004868 0 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004868 0 / 0
Q9BVA1 Tubulin beta-2B chain Structural C00004868 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00005372
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00005372
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00005372
23411 SIRT1, SIR2L1 sirtuin 1 C00005372

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#301500 Fabry disease P06280
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#611603 Lissencephaly 3; lis3 Q71U36
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (36)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)