PCIDB

Patersonia spp.

Species

KNApSAcK Entry

Organism name Patersonia spp.
Genus Patersonia
Family Iridaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Patersonia
Linked NCBI taxonomy ID 58967
Linked level genus

Family

Family in NCBI taxonomy Iridaceae
ID 26339

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005548 External link 512 Narcissin
/ Isorhamnetin 3-O-rutinoside
CHEMBL84174
CHEMBL258394
CHEMBL1711509
CHEMBL2165403
C031062
7 / 1 / 2 No. 1 No. 15
C00005372 External link 512 Hyperin
/ Hyperoside
/ Quercetin 3-O-galactoside
/ Quercetin 3-O-beta-D-galactoside
/ Quercetin 3-beta-galactopyranoside
/ Quercetin 3-O-beta-D-galactopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
C021304
38 / 43 / 34 4 / 0 No. 2 No. 15
C00005525 External link 512 Isorhamnetin 3-glucoside
/ Isorhamnetin 3-O-glucoside
/ Isorhamnetin 3-O-beta-D-glucoside
/ Isorhamnetin 3-O-beta-D-glucopyranoside
CHEMBL234316
CHEMBL516621
1 / 1 / 0 No. 2 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00005728 External link 512 Myricetin 3-galactoside
/ Myricetin 3-O-galactoside
CHEMBL462244
CHEMBL1221722
No. 2 No. 15
C00005729 External link 512 Myricetin 3-glucoside
/ Myricetin 3-O-beta-D-glucoside
/ Myricetin 3-O-beta-D-glucopyranoside
CHEMBL462244
CHEMBL1221722
No. 2 No. 15
C00005730 External link 512 Myricitrin
/ Myricetin 3-O-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnopyranoside
CHEMBL454576
CHEMBL522983
CHEMBL1599224
C008577
25 / 11 / 11 No. 2 No. 15

Human Protein / Gene in interactions

51 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UNA4 DNA polymerase iota Enzyme C00005372 C00005374 C00005548 C00005730 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005372 C00005374 C00005548 C00005730 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005372 C00005374 C00005730 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005372 C00005374 C00005730 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005372 C00005374 C00005730 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005372 C00005374 C00005730 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005372 C00005374 C00005730 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005372 C00005374 C00005730 1 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00005372 C00005730 1 / 1
P34949 Mannose-6-phosphate isomerase Enzyme C00005372 C00005730 1 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005372 C00005525 1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005372 C00005374 1 / 1
P06746 DNA polymerase beta Enzyme C00005372 C00005730 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005372 C00005730 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005372 C00005730 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005372 C00005730 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005374 C00005730 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005374 C00005730 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005372 C00005730 0 / 1
O75496 Geminin Unclassified protein C00005372 C00005548 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00005372 C00005730 1 / 4
P15121 Aldose reductase Enzyme C00005372 C00005374 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 C00005730 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005372 C00005730 4 / 3
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005372 3 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005372 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005548 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00005730 0 / 0
P14679 Tyrosinase Oxidoreductase C00005372 4 / 2
P06280 Alpha-galactosidase A Enzyme C00005372 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005372 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005372 0 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005372 2 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005548 0 / 0
P03372 Estrogen receptor NR3A1 C00005548 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00005372 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005548 0 / 1
P41143 Delta-type opioid receptor Opioid receptor C00005372 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005372 1 / 1
P41145 Kappa-type opioid receptor Opioid receptor C00005372 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005372 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005372 11 / 10
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005730 0 / 0
P04062 Glucosylceramidase Enzyme C00005372 6 / 4
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005372 0 / 3
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005730 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005730 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00005730 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00005372 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005372 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374
581 BAX, BCL2L4 BCL2-associated X protein C00005372
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00005372
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00005372
23411 SIRT1, SIR2L1 sirtuin 1 C00005372

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (37)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D010146 Pain C00005374