PCIDB

Magnolia kobus var. borealis

Species

KNApSAcK Entry

Organism name Magnolia kobus var. borealis
Genus Magnolia
Family Magnoliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Magnolia
Linked NCBI taxonomy ID 3402
Linked level genus

Family

Family in NCBI taxonomy Magnoliaceae
ID 3401

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00007196 External link 512 (+)-Epimagnolin
CHEMBL453302
CHEMBL519926
No. 38 No. 21
C00000640 External link 512 (+)-Eudesmin
CHEMBL519099
CHEMBL512865
CHEMBL523743
CHEMBL464352
CHEMBL1726879
C105875
2 / 0 / 0 No. 38 No. 21
C00000641 External link 512 Magnolin
/ (+)-Magnolin
CHEMBL453302
CHEMBL519926
C094148
No. 38 No. 21
C00000642 External link 512 (+)-Yangambin
CHEMBL510536
CHEMBL454592
CHEMBL1412125
4 / 2 / 0 No. 38 No. 21
C00000643 External link 512 Kobusin
/ (+)-Kobusin
/ (+)-Spinescin
/ Methylpiperitol
CHEMBL462822
No. 38 No. 21
C00000644 External link 512 Kobusinol A
No. 38 No. 21
C00007195 External link 512 (+)-Fargesin
CHEMBL462822
C058339
No. 38 No. 21
C00000647 External link 512 (+)-Phillygenin
CHEMBL457587
No. 38 No. 21
C00000659 External link 512 Medioresinol
/ (+)-Medioresinol
CHEMBL376507
CHEMBL513023
2 / 1 / 1 No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00000645 External link 512 Kobusinol B
No. 38 No. 21
C00000601 External link 512 (+)-Sesamin
CHEMBL43469
CHEMBL252915
CHEMBL1572261
CHEMBL1591714
CHEMBL1708854
CHEMBL1904496
CHEMBL1968861
C054125
20 / 24 / 15 0 / 5 No. 621 No. 21

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000601 C00000642 C00007190 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000601 C00000659 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000601 C00000659 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00000640 C00000642 0 / 0
O75496 Geminin Unclassified protein C00000601 C00000642 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000601 C00000642 2 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000601 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00000601 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000640 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000601 0 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000601 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000601 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000601 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000601 2 / 3
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000601 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000601 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000601 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000601 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000601 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000601 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000601 4 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00000601 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (21)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00000601
D002375 Catalepsy C00000601
D018476 Hypokinesia C00000601
D020244 Infarction, Middle Cerebral Artery C00000601
D020734 Parkinsonian Disorders C00000601