Species

KNApSAcK Entry

Organism name Ephedra sp.
Genus Ephedra
Family Ephedraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Ephedra sp.
Linked NCBI taxonomy ID 41991
Linked level species

Family

Family in NCBI taxonomy Ephedraceae
ID 3386

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Spermatophyta
ID 58024

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009282 External link 512 ent-Epicatechin-(2alpha->7,4alpha->8)-ent-epicatechin
CHEMBL286933
CHEMBL81646
CHEMBL450916
13 / 3 / 4 No. 16 No. 19
C00009255 External link 512 Mahuannin C
No. 16 No. 19
C00009256 External link 512 Mahuannin B
CHEMBL447152
No. 16 No. 19
C00009259 External link 512 Mahuannin A
CHEMBL447152
No. 16 No. 19
C00009280 External link 512 Proanthocyanidin A5'
CHEMBL286933
CHEMBL81646
CHEMBL450916
13 / 3 / 4 No. 16 No. 19
C00009279 External link 512 Pavetannin A2
CHEMBL286933
CHEMBL81646
CHEMBL450916
13 / 3 / 4 No. 16 No. 19
C00008805 External link 512 Epiafzelechin
CHEMBL159303
CHEMBL1326092
7 / 4 / 12 No. 52 No. 14
C00009274 External link 512 Ephedrannin A
No. 88

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q15139 Serine/threonine-protein kinase D1 Pkd C00009279 C00009280 C00009282 0 / 0
P49763 Placenta growth factor Unclassified protein C00009279 C00009280 C00009282 0 / 0
P41743 Protein kinase C iota type Iota C00009279 C00009280 C00009282 0 / 0
P24723 Protein kinase C eta type Eta C00009279 C00009280 C00009282 1 / 0
P15692 Vascular endothelial growth factor A Secreted protein C00009279 C00009280 C00009282 1 / 2
P05771 Protein kinase C beta type Alpha C00009279 C00009280 C00009282 0 / 0
P05129 Protein kinase C gamma type Alpha C00009279 C00009280 C00009282 1 / 1
Q05655 Protein kinase C delta type Delta C00009279 C00009280 C00009282 0 / 0
P17252 Protein kinase C alpha type Alpha C00009279 C00009280 C00009282 0 / 0
Q05513 Protein kinase C zeta type Iota C00009279 C00009280 C00009282 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00009279 C00009280 C00009282 0 / 0
Q02156 Protein kinase C epsilon type Eta C00009279 C00009280 C00009282 0 / 0
Q04759 Protein kinase C theta type Delta C00009279 C00009280 C00009282 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00008805 1 / 2
O00255 Menin Unclassified protein C00008805 2 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00008805 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00008805 0 / 1
Q9UM73 ALK tyrosine kinase receptor TKL serine/threonine protein kinase STKR type 1 subfamily C00008805 1 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00008805 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00008805 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603933 Microvascular complications of diabetes, susceptibility to, 1; mvcd1 P15692
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613014 Neuroblastoma, susceptibility to, 3; nblst3 Q9UM73
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723

KEGG DISEASE (16)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00036 Osteosarcoma P08684 (marker)
H00018 Gastric cancer P15692 (related)
H00021 Renal cell carcinoma P15692 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00014 Non-small cell lung cancer Q9UM73 (related)