Kopsia dasyrachis
Species
KNApSAcK Entry
| Organism name | Kopsia dasyrachis |
|---|---|
| Genus | Kopsia |
| Family | Apocynaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Kopsia |
|---|---|
| Linked NCBI taxonomy ID | 21101 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Apocynaceae |
|---|---|
| ID | 4056 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (33)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00038149
|
12-Methoxypleiocarpine
/ (-)-12-Methoxypleiocarpine |
CHEMBL314743
|
No. 230 |
|
||||
|
C00028696
|
Kopsinine D
/ Kopsilongine / (-)-Kopsilongine / N-Methoxycarbonyl-12-methoxykopsinaline / (-)-N-(Methoxycarbonyl)-12-methoxykopsinaline |
CHEMBL96596
|
No. 230 |
|
||||
|
C00024460
|
Kopsamine
/ (-)-Kopsinine F / (-)-N-Methoxycarbonyl-11,12-methylenedioxy-kopsinaline |
CHEMBL327561
|
C061457
|
No. 230 |
|
|||
|
C00039571
|
Kopsiflorine
|
CHEMBL406999
CHEMBL185142 |
No. 230 |
|
||||
|
C00024593
|
Pleiocarpine
|
CHEMBL328281
|
No. 230 |
|
||||
|
C00025214
|
Tetrahydroalstonine
|
CHEMBL122404
CHEMBL123325 CHEMBL498734 CHEMBL486933 CHEMBL1604074 CHEMBL2079609 |
32 / 28 / 31 | No. 246 | No. 4 |
|
||
|
C00025062
|
(+)-Isoeburnamine
|
CHEMBL2104946
|
No. 502 | No. 4 |
|
|||
|
C00027628
|
(+)-Vincamone
/ d-Eburnamonine / (+)-Eburnamonine / (+)-cis-Vincamone / (+)-cis-Eburnamonine |
CHEMBL1318553
CHEMBL1553441 CHEMBL1733074 CHEMBL1892145 |
C016422
|
14 / 20 / 16 | 2 / 0 | No. 502 | No. 4 |
|
|
C00024454
|
Kopsinine
/ (-)-Kopsinine |
CHEMBL93355
CHEMBL253984 |
C061491
|
No. 571 |
|
|||
|
C00038925
|
Danuphylline
/ (-)-Danuphylline |
CHEMBL328806
|
No. 880 |
|
||||
|
C00024580
|
Methyl 11,12-methylenedioxychanofruticosinate
|
No. 880 |
|
|||||
|
C00024547
|
Kopsidasinine
|
No. 880 |
|
|||||
|
C00024581
|
Methyl chanofruticosinate
|
No. 880 |
|
|||||
|
C00039570
|
Kopsifine
/ (+)-Kopsifine |
No. 937 |
|
|||||
|
C00039587
|
Kopsinarine
/ (+)-Kopsinarine |
No. 937 |
|
|||||
|
C00038124
|
11,12-Methylenedioxykopsine
|
No. 937 |
|
|||||
|
C00024589
|
Paucidactine B
|
No. 937 |
|
|||||
|
C00038949
|
Dasyrachine
/ (+)-Dasyrachine |
No. 937 |
|
|||||
|
C00038954
|
Decarbomethoxykopsifine
/ (+)-Decarbomethoxykopsifine |
No. 937 |
|
|||||
|
C00038053
|
(-)-Demethylnorpleiomutine
|
No. 1015 |
|
|||||
|
C00025064
|
Kopsoffinol
/ (+)-Kopsoffinol |
No. 1015 |
|
|||||
|
C00025050
|
Norpleiomutine
/ (-)-Norpleiomutine / N1-Demethylpleiomutine |
No. 1015 |
|
|||||
|
C00040153
|
Rhazinaline
|
No. 1217 |
|
|||||
|
C00026013
|
Pleiocarpamine
/ (+)-Pleiocarpamine |
No. 1352 |
|
|||||
|
C00024546
|
Kopsidasine N-oxide
|
No. 1719 |
|
|||||
|
C00024545
|
Kopsidasine
|
No. 1719 |
|
|||||
|
C00038127
|
11-Methoxykopsilongine N(4)-oxide
|
No. 2906 |
|
|||||
|
C00039572
|
Kopsiflorine N(4)-oxide
/ (-)-Kopsiflorine N(4)-oxide |
No. 2906 |
|
|||||
|
C00039588
|
Kopsine
|
CHEMBL1354781
|
3 / 7 / 8 | No. 3030 |
|
|||
|
C00039831
|
N-Carbomethoxy-5,22-dioxokopsane
|
No. 3030 |
|
|||||
|
C00024568
|
Leuconoxine
/ Diazaspiroleuconolam |
No. 6033 |
|
|||||
|
C00039559
|
Kinabalurine G
/ (+)-Kinabalurine G |
No. 6606 |
|
|||||
|
C00008974
|
Kopsirachine
|
No. 7551 |
|
Human Protein / Gene in interactions
40 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00025214 C00027628 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00025214 C00039588 | 2 / 5 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00025214 C00027628 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00025214 C00027628 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00025214 C00027628 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00025214 C00027628 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00025214 C00027628 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00025214 C00027628 | 0 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025214 C00039588 | 1 / 2 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00025214 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00025214 | 1 / 0 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00025214 | 4 / 4 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00025214 | 2 / 2 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00025214 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00025214 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00025214 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00027628 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00027628 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00025214 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00027628 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00027628 | 3 / 2 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00025214 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00025214 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025214 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00025214 | 3 / 3 |
| P55210 | Caspase-7 | C14 | C00025214 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00025214 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00027628 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025214 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025214 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00025214 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025214 | 0 / 0 |
| Q14145 | Kelch-like ECH-associated protein 1 | Unclassified protein | C00025214 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00025214 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025214 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025214 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00027628 | 1 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00025214 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00039588 | 4 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00027628 | 0 / 0 |
2 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1129 | CHRM2, HM2 | cholinergic receptor, muscarinic 2 |
C00027628
|
| 1132 | CHRM4, HM4, M4R | cholinergic receptor, muscarinic 4 |
C00027628
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #603903 | Sickle cell anemia |
P68871
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (34)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00020 | Colorectal cancer |
P68871
(marker)
|
| H00022 | Bladder cancer |
P68871
(marker)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|