PCIDB

KNApSAcK Metabolite C00025214

Metabolite

KNApSAcK Entry

id C00025214
Name Tetrahydroalstonine
CAS RN 6474-90-4
Standard InChI InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16-,19-/m0/s1
Standard InChI (Main Layer) InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 246

Link

ChEMBL

By standard InChI CHEMBL498734
By standard InChI Main Layer CHEMBL122404 CHEMBL123325 CHEMBL498734 CHEMBL486933 CHEMBL1604074 CHEMBL2079609

KEGG

By LinkDB C11682

CTD

By CAS RN

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL123325 CHEMBL498734 CHEMBL2079609 CHEMBL729201 (1) CHEMBL729203 (1)
CHEMBL729204 (1) CHEMBL729205 (1)
CHEMBL729206 (2) CHEMBL729208 (1)
CHEMBL758057 (1) CHEMBL754768 (1)
CHEMBL1614110 (2) CHEMBL1741321 (2)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1604074 CHEMBL1738312 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL1604074 CHEMBL1614158 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1604074 CHEMBL1794585 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL123325 CHEMBL1614544 (2)
11 / 10
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL122404 CHEMBL123325 CHEMBL648623 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL123325 CHEMBL1614027 (1) CHEMBL1741325 (2)
0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1604074 CHEMBL1614166 (1)
1 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL123325 CHEMBL1614225 (1)
4 / 4
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1604074 CHEMBL1794495 (1)
2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL123325 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL123325 CHEMBL498734 CHEMBL1738606 (2)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL1604074 CHEMBL1613918 (1)
1 / 1
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL122404 CHEMBL123325 CHEMBL647721 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL123325 CHEMBL1794467 (1)
0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein CHEMBL1604074 CHEMBL1738574 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL123325 CHEMBL1741322 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1604074 CHEMBL1613910 (1)
3 / 3
P55210 Caspase-7 C14 CHEMBL1604074 CHEMBL1613779 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL123325 CHEMBL1613777 (1) CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL123325 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1604074 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1604074 CHEMBL1737991 (1)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL122404 CHEMBL123325 CHEMBL644759 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL498734 CHEMBL1794536 (1)
0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein CHEMBL1604074 CHEMBL2114882 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL123325 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL123325 CHEMBL1604074 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL498734 CHEMBL1614364 (1)
1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL1604074 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL123325 CHEMBL498734 CHEMBL1604074 CHEMBL1614531 (3)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL123325 CHEMBL498734 CHEMBL1604074 CHEMBL1614531 (3)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#275210 Restrictive dermopathy, lethal P02545
#603903 Sickle cell anemia P68871
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (31)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00020 Colorectal cancer P68871 (marker)
H00022 Bladder cancer P68871 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)