Species

KNApSAcK Entry

Organism name Stevia polyphylla
Genus Stevia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stevia
Linked NCBI taxonomy ID 55669
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00021013 External link 512 5,10-bis-epi-Isoalantolactone
CHEMBL273254
CHEMBL137803
CHEMBL1410671
CHEMBL1451900
CHEMBL2000732
6 / 4 / 5 No. 69 No. 38
C00012380 External link 512 Inunolide
No. 107 No. 38
C00021018 External link 512 3beta-Acetoxy-desoxo-achalensolide
No. 157 No. 38
C00021015 External link 512 3alpha-Methoxy-desoxo-achalensolide
No. 178 No. 38
C00021016 External link 512 3beta-Hydroxy-desoxo-achalensolide
No. 178 No. 38
C00021014 External link 512 3alpha-Hydroxy-desoxo-achalensolide
No. 178 No. 38
C00021019 External link 512 3-Desoxo-achalensolide
No. 178 No. 38
C00021017 External link 512 3beta-Methoxy-desoxo-achalensolide
No. 178 No. 38
C00021012 External link 512 [3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,8,9a-Octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one
No. 358 No. 38
C00021011 External link 512 5alpha-Hydroxy-3,4-dihydroachalensolide
No. 358 No. 38
C00020950 External link 512 Achalensolide
/ 8-Epixerantholide
CHEMBL190054
CHEMBL407710
CHEMBL1995866
3 / 0 / 0 No. 601 No. 38
C00012425 External link 512 Bicyclogermacren
/ Bicyclogermacrene
/ (+)-Bicyclogermacrene
CHEMBL509566
No. 699 No. 38
C00021020 External link 512 3beta-Hydroxy-11beta,13-dihydro-desoxo-achalensolide
No. 1140
C00021021 External link 512 11beta,13-Dihydro-desoxo-achalensolide
No. 1140
C00012024 External link 512 Igalan
/ Elemasteriactinolide
No. 1542
C00012023 External link 512 [3aR-(3aalpha,5beta,6alpha,7aalpha)]-6-Ethenylhexahydro-6-methyl-3-methylene-5-(1-methylethenyl)-2(3H)-benzofuranone
No. 1542
C00011720 External link 512 Germacrene D
/ (-)-Germacrene D
CHEMBL105432
CHEMBL1836650
No. 2639 No. 38

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00021013 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00021013 0 / 1
Q04206 Transcription factor p65 Transcription Factor C00020950 0 / 0
P03372 Estrogen receptor NR3A1 C00021013 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00021013 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00021013 0 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00021013 1 / 1
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00020950 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00020950 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (5)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)