PCIDB

Dictamnus albus L.

Species

KNApSAcK Entry

Organism name Dictamnus albus L.
Genus Dictamnus
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dictamnus albus
Linked NCBI taxonomy ID 298346
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (17)

Species Activity
Dictamnus albus L. Antiimplantation
Dictamnus albus L. Antipyretic
Dictamnus albus L. Antiseptic
Dictamnus albus L. Antispasmodic
Dictamnus albus L. Cardiosedative
Dictamnus albus L. Contraceptive
Dictamnus albus L. Diuretic
Dictamnus albus L. Emmenagogue
Dictamnus albus L. Mutagenic
Dictamnus albus L. Nervine
Dictamnus albus L. phototoxic
Dictamnus albus L. Propecic
Dictamnus albus L. Sedative
Dictamnus albus L. Stimulant
Dictamnus albus L. Tonic
Dictamnus albus L. Uterotonic
Dictamnus albus L. Vermifuge

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00029763 External link 512 Auraptene
CHEMBL307341
C105832
28 / 25 / 26 3 / 0 No. 335
C00026447 External link 512 Isomaculosidine
/ 6,8-dimethoxydictamnine
No. 624 No. 7
C00026476 External link 512 Preskimmianine
CHEMBL487794
No. 781
C00011939 External link 512 Fraxinellone
CHEMBL257170
CHEMBL1595442
C075391
3 / 5 / 4 No. 1461

Human Protein / Gene in interactions

30 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13148 TAR DNA-binding protein 43 Unclassified protein C00011939 C00029763 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00029763 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00011939 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00029763 1 / 4
P16473 Thyrotropin receptor Glycohormone receptor C00011939 3 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00029763 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00029763 2 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00029763 2 / 0
O75496 Geminin Unclassified protein C00029763 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00029763 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00029763 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00029763 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00029763 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00029763 0 / 0
P06280 Alpha-galactosidase A Enzyme C00029763 1 / 1
P04062 Glucosylceramidase Enzyme C00029763 6 / 4
P28482 Mitogen-activated protein kinase 1 Erk C00029763 0 / 0
P56817 Beta-secretase 1 A1A C00029763 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00029763 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00029763 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00029763 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00029763 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00029763 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00029763 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00029763 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00029763 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00029763 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00029763 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00029763 1 / 4
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00029763 0 / 0

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00029763
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00029763
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00029763

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (29)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)