Species

KNApSAcK Entry

Organism name Hydrangea macrophylla var. thunbergii
Genus Hydrangea
Family Hydrangeaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hydrangea
Linked NCBI taxonomy ID 23109
Linked level genus

Family

Family in NCBI taxonomy Hydrangeaceae
ID 23097

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00015274 External link 512 Thunberginol A
/ 3-(3,4-dihydroxyphenyl)-8-hydroxyisocoumarin
CHEMBL68810
C079055
14 / 5 / 4 No. 54 No. 17
C00050256 External link 512 Thunberginol B
CHEMBL70501
C079056
20 / 16 / 45 No. 54 No. 17

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00015274 C00050256 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00015274 C00050256 2 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00015274 C00050256 0 / 0
P39748 Flap endonuclease 1 Enzyme C00015274 C00050256 0 / 0
O75496 Geminin Unclassified protein C00015274 C00050256 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00015274 C00050256 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00015274 C00050256 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00015274 C00050256 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00015274 C00050256 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00015274 C00050256 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00015274 C00050256 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00050256 0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00050256 2 / 2
P10696 Alkaline phosphatase, placental-like Enzyme C00050256 0 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00050256 1 / 2
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00050256 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00050256 3 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00015274 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00050256 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00015274 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00015274 2 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00050256 7 / 37
Q9HCT0 Fibroblast growth factor 22 Unclassified protein C00050256 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc Q14191
#133239 Esophageal cancer P04637
#612219 Ewing sarcoma; es P11308
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260500 Papilloma of choroid plexus; cpp P04637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (47)

KEGG name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00213 Hypophosphatasia P05186 (related)
H00023 Testicular cancer P10696 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)