Smilax glabra

• Index
• Plant Species
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Smilax glabra
Genus	Smilax
Family	Smilacaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Smilax glabra
Linked NCBI taxonomy ID	703614
Linked level	species

Family

Family in NCBI taxonomy	Smilacaceae
ID	4703

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Liliopsida
ID	4447

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00019005	7,2'-Dihydroxy-5'-methoxyisoflavone					No. 3	No. 15
C00014414	Smitilbin / (2R,3S)-3,5,7,3',5'-Pentahydroxyflavanone 3-rhamnoside	CHEMBL1257642		1 / 0 / 0		No. 12	No. 14
C00008703	Astilbin	CHEMBL486017 CHEMBL1159406 CHEMBL1159407 CHEMBL1314522	C099069	8 / 1 / 2		No. 12	No. 14
C00014415	Neosmitilbin / (2S,3S)-3,5,7,3',5'-Pentahydroxyflavanone 3-rhamnoside	CHEMBL1257642		1 / 0 / 0		No. 12	No. 14
C00000677	Distylin / Dihydroquercetin / (2R,3R)-Taxifolin	CHEMBL66 CHEMBL9249 CHEMBL337309 CHEMBL1492383	C003377	65 / 41 / 37	29 / 1	No. 42	No. 14
C00037831	Smiglaside D					No. 334
C00037828	Smiglaside A					No. 334
C00037829	Smiglaside B					No. 334
C00037832	Smiglaside E					No. 334
C00037830	Smiglaside C					No. 418
C00033906	Helonioside A	CHEMBL2151691				No. 418

Human Protein / Gene in interactions

73 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000677 C00008703	0 / 0
P49327	Fatty acid synthase	Transferase	C00014414 C00014415	0 / 0
O00255	Menin	Unclassified protein	C00000677	2 / 5
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000677	2 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00000677	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000677	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000677	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000677	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000677	1 / 1
P39900	Macrophage metalloelastase	M10A	C00000677	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000677	2 / 2
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000677	1 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000677	0 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000677	1 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00000677	4 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000677	0 / 1
P07237	Protein disulfide-isomerase	Enzyme	C00008703	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000677	1 / 2
P41145	Kappa-type opioid receptor	Opioid receptor	C00000677	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00000677	1 / 1
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000677	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000677	0 / 0
O75496	Geminin	Unclassified protein	C00000677	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000677	0 / 0
P03956	Interstitial collagenase	M10A	C00000677	0 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00000677	1 / 1
P11308	Transcriptional regulator ERG	Unclassified protein	C00008703	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00000677	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00008703	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00000677	0 / 0
P45452	Collagenase 3	M10A	C00000677	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000677	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000677	0 / 0
P56817	Beta-secretase 1	A1A	C00000677	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000677	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00000677	1 / 3
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000677	3 / 3
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00000677	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000677	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000677	5 / 2
P35372	Mu-type opioid receptor	Opioid receptor	C00000677	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000677	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000677	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000677	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000677	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000677	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000677	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000677	4 / 3
P08254	Stromelysin-1	M10A	C00000677	1 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000677	0 / 0
P24298	Alanine aminotransferase 1	Enzyme	C00000677	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000677	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000677	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000677	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000677	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000677	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000677	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000677	1 / 4
Q05513	Protein kinase C zeta type	Iota	C00000677	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000677	0 / 1
Q02156	Protein kinase C epsilon type	Eta	C00000677	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00000677	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000677	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000677	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00000677	1 / 1
P05771	Protein kinase C beta type	Alpha	C00000677	0 / 0
P24723	Protein kinase C eta type	Eta	C00000677	1 / 0
P41743	Protein kinase C iota type	Iota	C00000677	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000677	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00008703	0 / 0
P19784	Casein kinase II subunit alpha'	Ck2	C00008703	0 / 0
P67870	Casein kinase II subunit beta	REG serine/threonine protein kinase family	C00008703	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00008703	0 / 0

29 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00000677
335	APOA1	apolipoprotein A-I	C00000677
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00000677
8900	CCNA1	cyclin A1	C00000677
993	CDC25A, CDC25A2	cell division cycle 25A (EC:3.1.3.48)	C00000677
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00000677
1630	DCC, CRC18, CRCR1, IGDCC1, MRMV1	deleted in colorectal carcinoma	C00000677
1950	EGF, HOMG4, URG	epidermal growth factor	C00000677
8817	FGF18, FGF-18, ZFGF5	fibroblast growth factor 18	C00000677
2248	FGF3, HBGF-3, INT2	fibroblast growth factor 3	C00000677
2621	GAS6, AXLLG, AXSF	growth arrest-specific 6	C00000677
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00000677
2944	GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1	glutathione S-transferase mu 1 (EC:2.5.1.18)	C00000677
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000677
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000677
3458	IFNG, IFG, IFI	interferon, gamma	C00000677
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000677
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000677
4547	MTTP, ABL, MTP	microsomal triglyceride transfer protein	C00000677
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00000677
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000677
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00000677
5921	RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	C00000677
6772	STAT1, CANDF7, ISGF-3, STAT91	signal transducer and activator of transcription 1, 91kDa	C00000677
7187	TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1	TNF receptor-associated factor 3	C00000677
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000677
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00000677
7507	XPA, XP1, XPAC	xeroderma pigmentosum, complementation group A	C00000677
7518	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	C00000677

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions