Species

KNApSAcK Entry

Organism name Catharanthus ovalis
Genus Catharanthus
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Catharanthus ovalis
Linked NCBI taxonomy ID 1167200
Linked level species

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00024505 External link 512 19S-Hydroxytabersonine
/ (20S)-20-Hydroxytabersonine
/ 6,7-Didehydro-20-epiminovincinine
C00024524 External link 512 Cathovalinine
No. 61 No. 4
C00024501 External link 512 19R-Hydroxytabersonine
No. 61 No. 4
C00024498 External link 512 19S-Vindolinine
/ 19-Epivindolinine
/ 20-Epivindolinine
/ 20-epi-Vindolinine
CHEMBL1165590
CHEMBL1330793
15 / 8 / 12 No. 527
C00024541 External link 512 Kitramine
No. 527
C00024462 External link 512 (-)-Venalstonine
No. 527
C00024540 External link 512 Kitraline
No. 527
C00024461 External link 512 (-)-Venalstonidine
/ 6,7-Epoxykopsinine
No. 571
C00024528 External link 512 Deacetylcathovaline
No. 1218 No. 4
C00024523 External link 512 Cathovaline
/ Cathanneine
No. 1218 No. 4
C00024490 External link 512 14-Hydroxycathovaline
No. 1218 No. 4
C00024616 External link 512 NSC 94038
/ Vindorosine
/ Vindorosin
/ Vindolidin
/ Vindolidine
/ (+)-Vindorosine
/ Demethoxyvindoline
No. 1218 No. 4
C00024613 External link 512 Vindoline
/ Vindolin
/ NSC 91994
/ (-)-Vindoline
CHEMBL526546
CHEMBL1317962
CHEMBL2001832
C009667
3 / 1 / 1 No. 1218 No. 4
C00024615 External link 512 Vindolinine
/ 19R-vindolinine
/ (-)-Vindolinine
C009668
No. 2586

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein C00024498 1 / 1
P08183 Multidrug resistance protein 1 drug C00024613 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00024498 2 / 0
O75496 Geminin Unclassified protein C00024498 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00024498 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00024498 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00024498 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00024498 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00024498 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00024613 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00024498 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00024498 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00024613 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00024498 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00024498 1 / 0
O00255 Menin Unclassified protein C00024498 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00024498 1 / 2
P01215 Glycoprotein hormones alpha chain Unclassified protein C00024498 0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257220 Niemann-pick disease, type c1; npc1 O15118
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (13)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00036 Osteosarcoma P08684 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)