Species

KNApSAcK Entry

Organism name Stephania hernandifolia (Willd.)Walp.
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania hernandifolia
Linked NCBI taxonomy ID 152366
Linked level species

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025273 External link 512 (+)-Stephasubine
No. 10 No. 4
C00025662 External link 512 (+)-Limacine
/ (+)-Fangchinoline
CHEMBL504256
CHEMBL509803
CHEMBL500614
12 / 6 / 3 No. 10 No. 4
C00025660 External link 512 Epistephanine
/ (+)-Epistephanine
CHEMBL2063775
No. 10 No. 4
C00025989 External link 512 O-Methylhernandine
/ N-Methylstephuline
CHEMBL1096481
3 / 0 / 0 No. 395
C00025131 External link 512 Stephisoferuline
CHEMBL1972351
No. 530
C00025111 External link 512 Hernandolinol
No. 559 No. 4
C00025102 External link 512 Aknadinine
/ 4-Demethylhasubanonine
/ O4-Demethylhasubanonine
CHEMBL1098359
C099121
3 / 0 / 0 No. 559 No. 4

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P41145 Kappa-type opioid receptor Opioid receptor C00025102 C00025989 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025102 C00025989 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00025102 C00025989 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025662 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00025662 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025662 1 / 1
P39748 Flap endonuclease 1 Enzyme C00025662 0 / 0
P08183 Multidrug resistance protein 1 drug C00025662 1 / 0
O75496 Geminin Unclassified protein C00025662 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00025662 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025662 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025662 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00025662 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025662 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025662 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc P84022
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (3)

KEGG name UniProt
H00079 Asthma P07550 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)