Species

KNApSAcK Entry

Organism name Leontice darwasica
Genus Leontice
Family Berberidaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Leontice
Linked NCBI taxonomy ID 168832
Linked level genus

Family

Family in NCBI taxonomy Berberidaceae
ID 41773

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00026289 External link 512 (+)-Darvasamine
CHEMBL204860
CHEMBL383443
CHEMBL525227
CHEMBL1396816
CHEMBL1733145
CHEMBL1824581
5 / 3 / 7 No. 85 No. 3
C00026290 External link 512 Darvasine
/ (+)-Darvasine
No. 4993

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11387 DNA topoisomerase 1 Isomerase C00026289 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00026289 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00026289 0 / 0
O00255 Menin Unclassified protein C00026289 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00026289 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (3)

OMIM preferred title UniProt
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (7)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)