| Organism name | Mentha spp. | 
|---|---|
| Genus | Mentha | 
| Family | Labiatae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Mentha | 
|---|---|
| Linked NCBI taxonomy ID | 21819 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Lamiaceae | 
|---|---|
| ID | 4136 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00003892   | 6-Hydroxyluteolin 7,3'-dimethyl ether / 5,6,4'-Trihydroxy-7,3'-dimethoxyflavone / 5,6-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one | No. 3 | No. 15 |   | ||||
| C00003931   | Thymonin / Majoranin / Mucroflavone B / 5,6,4'-Trihydroxy-7,8,3'-trimethoxyflavone / 5,6-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one | CHEMBL478416 | No. 3 | No. 15 |   | |||
| C00000968   | Hesperetin | CHEMBL88169 CHEMBL399121 CHEMBL1589200 | C013015 | 42 / 50 / 65 | 18 / 3 | No. 25 | No. 14 |   | 
| C00000970   | Hesperidin | CHEMBL265606 CHEMBL449317 CHEMBL1314714 CHEMBL1328143 CHEMBL1535112 CHEMBL1574000 CHEMBL2140112 | D006569 | 24 / 9 / 14 | 10 / 5 | No. 48 | No. 14 |   | 
| C00011057   | (+)-beta-Fenchene / (1R)-2,2-Dimethyl-5-methylenebicyclo[2.2.1]heptane | No. 476 | No. 35 |   | ||||
| C00011058   | (-)-alpha-Fenchene / (-)-7,7-dimethyl-2-methylenenorbornane | No. 476 | No. 35 |   | ||||
| C00003110   | Caryophyllene / (E)-Caryophyllene / beta-Caryophyllene / (-)-(E)-Caryophyllene / (E)-beta-Caryophyllene | CHEMBL445740 CHEMBL448700 | 2 / 3 / 7 | No. 478 | No. 38 |   | ||
| C00010932   | (S)-(-)-alpha-Terpineol / (S)-(-)-p-Menth-1-en-8-ol | CHEMBL447597 CHEMBL449810 | 3 / 16 / 11 | No. 983 | No. 35 |   | ||
| C00010931   | (R)-(+)-alpha-Terpineol / (R)-(+)-p-Menth-1-en-8-ol | CHEMBL447597 CHEMBL449810 | 3 / 16 / 11 | No. 983 | No. 35 |   | ||
| C00010925   | trans-(-)-Piperitol / (3S,4S)-(-)-p-Menth-1-en-3-ol | No. 1052 | No. 35 |   | ||||
| C00000811   | (-)-Menthone | CHEMBL276311 CHEMBL1719455 | 1 / 0 / 0 | No. 1288 | No. 35 |   | ||
| C00007453   | Cyclohexane / beta-Elemene | CHEMBL448502 CHEMBL479707 | No. 1400 |   | ||||
| C00003051   | alpha-Phellandrene | CHEMBL455041 | C005403 | No. 1898 | No. 35 |   | ||
| C00010947   | (1S,4R)-(+)-Isodihydrocarvone | No. 2206 | No. 35 |   | ||||
| C00003061   | gamma-Terpinene / 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene | CHEMBL449693 | C018669 | No. 2468 | No. 35 |   | ||
| C00010898   | p-Menthan-4-ol | No. 3619 |   | |||||
| C00000861   | Terpinolene | CHEMBL454697 | C027009 | 1 / 0 | No. 3725 |   | ||
| C00000821   | (+)-trans-Sabinene hydrate | No. 3782 | No. 35 |   | ||||
| C00003054   | (+)-Piperitone | No. 4185 | No. 35 |   | ||||
| C00000827   | (+)-Pulegone / (+)-(R)-Pulegone | CHEMBL366136 CHEMBL1898498 | 2 / 0 / 0 | No. 4648 | No. 35 |   | ||
| C00010889   | Pulespenone / Piperitenone / 3-Terpinolenone / p-Mentha-1,4(8)-dien-3-one | CHEMBL54161 | C044956 | No. 5232 | No. 35 |   | ||
| C00003049   | (+)-Menthofuran / (R)-(+)-Menthofuran | CHEMBL1522900 | 10 / 8 / 9 | No. 5653 | No. 36 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000968 C00000970 C00003049 | 1 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000968 C00000970 C00003049 | 0 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000968 C00000970 C00003049 | 0 / 1 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000968 C00000970 C00003049 | 1 / 1 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000968 C00000970 C00003049 | 0 / 0 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000968 C00000970 | 0 / 0 | 
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00010931 C00010932 | 5 / 1 | 
| O00255 | Menin | Unclassified protein | C00000970 C00003110 | 2 / 5 | 
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00010931 C00010932 | 3 / 0 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000827 C00000968 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000968 C00000970 | 0 / 0 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000968 C00000970 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000968 C00003049 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00010931 C00010932 | 11 / 10 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000968 C00003049 | 3 / 2 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000970 C00003110 | 1 / 2 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000970 | 0 / 0 | 
| Q9GZU7 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 | Enzyme | C00000970 | 0 / 0 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 | 
| P62158 | Calmodulin | Unclassified protein | C00000970 | 1 / 0 | 
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00003049 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000968 | 0 / 0 | 
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000811 | 0 / 0 | 
| O75496 | Geminin | Unclassified protein | C00000968 | 0 / 0 | 
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000968 | 0 / 0 | 
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000968 | 4 / 2 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00000970 | 1 / 1 | 
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00000970 | 1 / 2 | 
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00000968 | 1 / 4 | 
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000968 | 5 / 3 | 
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000968 | 4 / 4 | 
| P04745 | Alpha-amylase 1 | Enzyme | C00000968 | 0 / 0 | 
| Q96RI1 | Bile acid receptor | NR1H4 | C00000827 | 0 / 0 | 
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00000968 | 0 / 0 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000968 | 0 / 0 | 
| P06746 | DNA polymerase beta | Enzyme | C00000970 | 0 / 0 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000968 | 3 / 3 | 
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000968 | 2 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000968 | 2 / 2 | 
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000968 | 1 / 1 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000968 | 0 / 0 | 
| P02647 | Apolipoprotein A-I | Unclassified protein | C00000968 | 3 / 2 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00000968 | 1 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000968 | 0 / 0 | 
| P14618 | Pyruvate kinase PKM | Enzyme | C00000968 | 0 / 0 | 
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00000968 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00000968 | 1 / 1 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000970 | 0 / 0 | 
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000968 | 0 / 0 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000970 | 0 / 0 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000968 | 4 / 1 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000968 | 4 / 3 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003049 | 0 / 0 | 
| P10275 | Androgen receptor | NR3C4 | C00003049 | 3 / 4 | 
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000968 | 0 / 0 | 
| Q9Y251 | Heparanase | Enzyme | C00000970 | 0 / 0 | 
| P37173 | TGF-beta receptor type-2 | TKL dual-specificity kinase STKR type 2 subfamily | C00000968 | 4 / 3 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000970 | 0 / 0 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000970 | 1 / 1 | 
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000968 | 1 / 0 | 
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000968 | 7 / 37 | 
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00000968 | 0 / 0 | 
| Q02410 | Amyloid beta A4 precursor protein-binding family A member 1 | Unclassified protein | C00000970 | 0 / 0 | 
| Q00975 | Voltage-dependent N-type calcium channel subunit alpha-1B | N-TYPE | C00000970 | 0 / 0 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000970 | 0 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | C00000968 | 
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | C00000968 | 
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | C00000968 | 
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor | C00000968 | 
| 581 | BAX, BCL2L4 | BCL2-associated X protein | C00000968 | 
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 | C00000968 | 
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | C00000968 | 
| 847 | CAT | catalase (EC:1.11.1.6) | C00000968 | 
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 | C00000968 | 
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) | C00000968 | 
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) | C00000968 | 
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | C00000968 | 
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | C00000968 | 
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic | C00000968 | 
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00000968 | 
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00000968 | 
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 | C00000968 | 
| 7402 | UTRN, DMDL, DRP, DRP1 | utrophin | C00000968 | 
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | C00000861 | 
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 | C00000970 | 
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta | C00000970 | 
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) | C00000970 | 
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 | C00000970 | 
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) | C00000970 | 
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) | C00000970 | 
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | C00000970 | 
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | C00000970 | 
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor | C00000970 | 
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 | C00000970 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #202300 | Adrenocortical carcinoma, hereditary; adcc | P04637 | 
| #105200 | Amyloidosis, familial visceral | P02647 | 
| #300068 | Androgen insensitivity syndrome; ais | P10275 | 
| #312300 | Androgen insensitivity, partial; pais | P10275 | 
| #208900 | Ataxia-telangiectasia; at | Q13315 | 
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 | P04637 | 
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 | P22309 | 
| #614490 | Blood group, junior system; jr | Q9UNQ0 | 
| %606641 | Body mass index; bmi | P37231 | 
| #114480 | Breast cancer | P38398 | 
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 | P38398 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #609338 | Carotid intimal medial thickness 1 | P37231 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #614331 | Colorectal cancer, hereditary nonpolyposis, type 6; hnpcc6 | P37173 | 
| #218800 | Crigler-najjar syndrome, type i | P22309 P22310 | 
| #606785 | Crigler-najjar syndrome, type ii | P22309 P22310 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #133239 | Esophageal cancer | P04637 P37173 | 
| #612219 | Ewing sarcoma; es | P11308 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #143500 | Gilbert syndrome | P22309 P22310 | 
| #137750 | Glaucoma 1, open angle, a; glc1a | Q16678 | 
| #231300 | Glaucoma 3, primary congenital, a; glc3a | Q16678 | 
| #137760 | Glaucoma, primary open angle; poag | Q16678 | 
| #137800 | Glioma susceptibility 1; glm1 | O75874 P37231 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn | P22309 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #604091 | Hypoalphalipoproteinemia, primary | P02647 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #151623 | Li-fraumeni syndrome 1; lfs1 | P04637 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 | P37231 | 
| #610168 | Loeys-dietz syndrome, type 1b; lds1b | P37173 | 
| #610380 | Loeys-dietz syndrome, type 2b; lds2b | P37173 | 
| #211980 | Lung cancer | P04637 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #257220 | Niemann-pick disease, type c1; npc1 | O15118 | 
| #601665 | Obesity | P37231 | 
| #167000 | Ovarian cancer | P38398 | 
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 | P38398 | 
| #260500 | Papilloma of choroid plexus; cpp | P04637 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #604229 | Peters anomaly | Q16678 | 
| #172700 | Pick disease of brain | P10636 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 | P10275 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #275355 | Squamous cell carcinoma, head and neck; hnscc | P04637 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #205400 | Tangier disease; tgd | P02647 | 
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 | Q9UNQ0 | 
| #614916 | Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 | P62158 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| #112100 | Yt blood group antigen | P22303 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) P04637 (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00136 | Niemann-Pick disease type C (NPC) | O15118
                            (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) P37231 (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00845 | Familial amyloidosis | P02647
                            (related) | 
| H00930 | Hypoalphalipoproteinemia | P02647
                            (related) | 
| H00004 | Chronic myeloid leukemia (CML) | P04637
                            (related) | 
| H00005 | Chronic lymphocytic leukemia (CLL) | P04637
                            (related) Q13315 (related) | 
| H00006 | Hairy-cell leukemia | P04637
                            (related) | 
| H00008 | Burkitt lymphoma | P04637
                            (related) | 
| H00009 | Adult T-cell leukemia | P04637
                            (related) | 
| H00010 | Multiple myeloma | P04637
                            (related) | 
| H00013 | Small cell lung cancer | P04637
                            (related) | 
| H00014 | Non-small cell lung cancer | P04637
                            (related) | 
| H00015 | Malignant pleural mesothelioma | P04637
                            (related) | 
| H00016 | Oral cancer | P04637
                            (related) P04637 (marker) | 
| H00017 | Esophageal cancer | P04637
                            (related) P04637 (marker) | 
| H00018 | Gastric cancer | P04637
                            (related) | 
| H00019 | Pancreatic cancer | P04637
                            (related) P04637 (marker) | 
| H00020 | Colorectal cancer | P04637
                            (related) P04637 (marker) P37173 (related) | 
| H00022 | Bladder cancer | P04637
                            (related) | 
| H00025 | Penile cancer | P04637
                            (related) P04637 (marker) | 
| H00026 | Endometrial Cancer | P04637
                            (related) | 
| H00027 | Ovarian cancer | P04637
                            (related) P38398 (related) | 
| H00028 | Choriocarcinoma | P04637
                            (related) | 
| H00029 | Vulvar cancer | P04637
                            (related) | 
| H00031 | Breast cancer | P04637
                            (related) P38398 (related) | 
| H00032 | Thyroid cancer | P04637
                            (related) P37231 (related) | 
| H00036 | Osteosarcoma | P04637
                            (related) P08684 (marker) | 
| H00038 | Malignant melanoma | P04637
                            (related) | 
| H00039 | Basal cell carcinoma | P04637
                            (related) | 
| H00040 | Squamous cell carcinoma | P04637
                            (related) | 
| H00041 | Kaposi's sarcoma | P04637
                            (related) | 
| H00042 | Glioma | P04637
                            (related) P04637 (marker) | 
| H00044 | Cancer of the anal canal | P04637
                            (related) | 
| H00046 | Cholangiocarcinoma | P04637
                            (related) | 
| H00047 | Gallbladder cancer | P04637
                            (related) | 
| H00048 | Hepatocellular carcinoma | P04637
                            (related) | 
| H00055 | Laryngeal cancer | P04637
                            (related) P04637 (marker) | 
| H00881 | Li-Fraumeni syndrome | P04637
                            (related) | 
| H01007 | Choroid plexus papilloma | P04637
                            (related) | 
| H00021 | Renal cell carcinoma | P04637
                            (marker) | 
| H00024 | Prostate cancer | P10275
                            (related) P11308 (related) | 
| H00062 | Spinal and bulbar muscular atrophy (SBMA) | P10275
                            (related) | 
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) | P10275
                            (related) | 
| H00609 | 46,XY disorders of sex development (Other) | P10275
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00035 | Ewing's sarcoma | P11308
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P16473
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H00208 | Hyperbilirubinemia | P22309
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00800 | Loeys-Dietz syndrome (LDS) | P37173
                            (related) | 
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) | P37173
                            (related) | 
| H00409 | Type II diabetes mellitus | P37231
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q03164
                            (related) Q03164 (marker) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00064 | Ataxia telangiectasia (AT) | Q13315
                            (related) | 
| H00094 | DNA repair defects | Q13315
                            (related) | 
| H00848 | Ataxia with ocular apraxia (AOA) | Q13315
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00612 | Primary open angle glaucoma | Q16678
                            (related) | 
| H01075 | Peters anomaly | Q16678
                            (related) | 
| H01159 | Anterior segment dysgenesis (ASD) | Q16678
                            (related) | 
| H01203 | Primary congenital glaucoma (PCG) | Q16678
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) Q9NUW8 (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) | 
| MESH or OMIM | name | KNApSAcK metabolite | 
|---|---|---|
| D056486 | Drug-Induced Liver Injury | C00000968 C00000970 | 
| D058186 | Acute Kidney Injury | C00000970 | 
| D000230 | Adenocarcinoma | C00000968 | 
| D003110 | Colonic Neoplasms | C00000968 | 
| D055371 | Acute Lung Injury | C00000970 | 
| D008171 | Lung Diseases | C00000970 | 
| D012128 | Respiratory Distress Syndrome, Adult | C00000970 |