Species

KNApSAcK Entry

Organism name Tanacetum longifolium
Genus Tanacetum
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tanacetum
Linked NCBI taxonomy ID 99105
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00037436 External link 512 Ludartin
No. 227 No. 38
C00033803 External link 512 Eicosanyl-trans-p-coumarate
No. 447
C00021309 External link 512 alpha-Himachalene
No. 478 No. 38
C00037113 External link 512 Epizonarene
/ (+)-Epizonarene
No. 574
C00034757 External link 512 (Z)-Nerolidol
/ cis-Nerolidol
CHEMBL25424
CHEMBL508801
CHEMBL561014
CHEMBL1923157
3 / 3 / 1 No. 726 No. 38
C00029422 External link 512 1-Octadecanol
/ Octadecan-1-ol
CHEMBL24640
C009316
3 / 11 / 10 No. 732
C00030805 External link 512 1-Docosanol
/ n-Docosanol
CHEMBL1200453
C529236
1 / 0 / 0 No. 732
C00021283 External link 512 Cyperene
No. 1454
C00029970 External link 512 cis-alpha-Bergamotene
No. 1653 No. 38
C00035857 External link 512 Octane
/ n-Octane
CHEMBL134886
C026728
No. 1749
C00003046 External link 512 Geranyl acetate
/ trans-Geranyl acetate
/ Acetic acid geraniol ester
CHEMBL1369384
5 / 3 / 4 No. 2157 No. 34
C00035138 External link 512 Neryl acetate
CHEMBL1369384
5 / 3 / 4 No. 2157 No. 34
C00037604 External link 512 p-Cymen-9-ol
No. 2172 No. 35
C00029544 External link 512 4-Terpineol
/ Terpin-4-ol
/ Terpineol-4
/ Terpinen-4-ol
CHEMBL507795
C034019
1 / 3 / 0 No. 2215
C00000830 External link 512 cis-Sabinene hydrate
No. 3782 No. 35
C00000821 External link 512 (+)-trans-Sabinene hydrate
No. 3782 No. 35

Human Protein / Gene in interactions

29 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P16050 Arachidonate 15-lipoxygenase Enzyme C00003046 C00034757 C00035138 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003046 C00035138 0 / 0
P10275 Androgen receptor NR3C4 C00003046 C00035138 3 / 4
P00352 Retinal dehydrogenase 1 Enzyme C00003046 C00035138 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003046 C00035138 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00034757 3 / 1
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00030805 0 / 0
O75496 Geminin Unclassified protein C00029422 0 / 0
P02545 Prelamin-A/C Unclassified protein C00029422 11 / 10
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00034757 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00029422 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00029544 3 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#143500 Gilbert syndrome P22310
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (27)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)