Species

KNApSAcK Entry

Organism name Cymbopogon martinii
Genus Cymbopogon
Family Poaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cymbopogon martinii
Linked NCBI taxonomy ID 79837
Linked level species

Family

Family in NCBI taxonomy Poaceae
ID 4479

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00021969 External link 512 beta-Caryophyllene alcohol
CHEMBL1374805
2 / 0 / 0 No. 161 No. 38
C00010883 External link 512 Carveol
/ p-Mentha-1,8-dien-6-ol
CHEMBL1385229
CHEMBL1907992
CHEMBL1908058
C075856
6 / 15 / 40 1 / 0 No. 1555 No. 35
C00000845 External link 512 Geraniol
CHEMBL25719
CHEMBL452683
96 / 41 / 41 No. 1575 No. 34
C00003046 External link 512 Geranyl acetate
/ trans-Geranyl acetate
/ Acetic acid geraniol ester
CHEMBL1369384
5 / 3 / 4 No. 2157 No. 34
C00010947 External link 512 (1S,4R)-(+)-Isodihydrocarvone
No. 2206 No. 35
C00010887 External link 512 (+)-cis-p-Mentha-2,8-dien-1-ol
CHEMBL504494
CHEMBL451087
No. 3348
C00010886 External link 512 (+)-trans-p-Mentha-2,8-dien-1-ol
CHEMBL504494
CHEMBL451087
No. 3348
C00010889 External link 512 Pulespenone
/ Piperitenone
/ 3-Terpinolenone
/ p-Mentha-1,4(8)-dien-3-one
CHEMBL54161
C044956
No. 5232 No. 35
C00010811 External link 512 Cymbodiacetal
No. 8289

Human Protein / Gene in interactions

106 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P00352 Retinal dehydrogenase 1 Enzyme C00003046 C00021969 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000845 C00003046 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00000845 C00003046 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000845 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000845 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000845 2 / 2
P08246 Neutrophil elastase S1A C00000845 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000845 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000845 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000845 0 / 0
P29466 Caspase-1 C14 C00000845 0 / 0
P17252 Protein kinase C alpha type Alpha C00000845 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000845 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000845 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000845 2 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00010883 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00000845 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000845 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000845 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000845 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000845 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000845 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000845 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000845 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000845 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000845 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000845 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000845 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000845 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000845 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00000845 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00000845 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000845 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000845 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000845 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000845 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000845 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000845 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000845 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000845 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000845 1 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000845 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000845 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00010883 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000845 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000845 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000845 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000845 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000845 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000845 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000845 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000845 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000845 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000845 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000845 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000845 0 / 0
P08311 Cathepsin G S1A C00000845 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000845 1 / 0
P03956 Interstitial collagenase M10A C00000845 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000845 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00010883 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00021969 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000845 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000845 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000845 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000845 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000845 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000845 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000845 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000845 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000845 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000845 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000845 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00010883 7 / 37
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000845 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000845 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000845 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000845 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000845 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000845 0 / 0
P03372 Estrogen receptor NR3A1 C00000845 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000845 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000845 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000845 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000845 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000845 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000845 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000845 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000845 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000845 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00010883 3 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000845 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000845 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000845 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00010883 5 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003046 0 / 0
P10275 Androgen receptor NR3C4 C00003046 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000845 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000845 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000845 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000845 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000845 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000845 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000845 0 / 0
O00255 Menin Unclassified protein C00000845 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000845 1 / 2

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00010883

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (70)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)