PCIDB

Annona squamosa

Species

KNApSAcK Entry

Organism name Annona squamosa
Genus Annona
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Annona squamosa
Linked NCBI taxonomy ID 301693
Linked level species

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Natural Activity

List (63)

Species Activity
Annona squamosa L. Abortifacient
Annona squamosa L. Adrenergic
Annona squamosa L. Anthelmintic
Annona squamosa L. Anti-NO
Annona squamosa L. Antiaggregant
Annona squamosa L. Anticancer
Annona squamosa L. Anticancer, breast
Annona squamosa L. Anticancer, pancreas
Annona squamosa L. Anticancer, prostate
Annona squamosa L. Antidiabetic
Annona squamosa L. Antifertility
Annona squamosa L. Antiinflammatory
Annona squamosa L. Antileukemic
Annona squamosa L. Antimalarial
Annona squamosa L. Antimicrobial
Annona squamosa L. Antioxidant
Annona squamosa L. Antiradicular
Annona squamosa L. Antiseptic
Annona squamosa L. Antispasmodic
Annona squamosa L. Antitumor
Annona squamosa L. Antiviral
Annona squamosa L. Apoptotic
Annona squamosa L. Astringent
Annona squamosa L. Bactericide
Annona squamosa L. Bronchodilator
Annona squamosa L. Calcium-Channel-Blocker
Annona squamosa L. Cardiotonic
Annona squamosa L. Cathartic
Annona squamosa L. Contraceptive
Annona squamosa L. Cytotoxic
Annona squamosa L. Diuretic
Annona squamosa L. Emmenagogue
Annona squamosa L. Fungicide
Annona squamosa L. Hepatoprotective
Annona squamosa L. Hypertensive
Annona squamosa L. Hypocholesterolemic
Annona squamosa L. Hypoglycemic
Annona squamosa L. Hypotriglyceridemic
Annona squamosa L. Immunomodulator
Annona squamosa L. Insecticide
Annona squamosa L. Insectifuge
Annona squamosa L. Larvicide
Annona squamosa L. Laxative
Annona squamosa L. Mosquitocide
Annona squamosa L. Myorelaxant
Annona squamosa L. Myotonic
Annona squamosa L. Orexigenic
Annona squamosa L. Oxytocic
Annona squamosa L. Pectoral
Annona squamosa L. Pediculicide
Annona squamosa L. Pesticide
Annona squamosa L. Piscicide
Annona squamosa L. Purgative
Annona squamosa L. Sedative
Annona squamosa L. Soporific
Annona squamosa L. Spasmogenic
Annona squamosa L. Stomachic
Annona squamosa L. Suppurative
Annona squamosa L. Syncope
Annona squamosa L. Tonic
Annona squamosa L. Uterotonic
Annona squamosa L. Vasorelaxant
Annona squamosa L. Vermifuge

Metabolite list (44)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00040607 External link 512 Uvariamicin II
CHEMBL447985
No. 6 No. 70
C00044326 External link 512 Squamostatin E
CHEMBL448616
CHEMBL448377
CHEMBL2016769
No. 6 No. 70
C00001301 External link 512 Asimicin
CHEMBL13710
CHEMBL61332
CHEMBL68179
CHEMBL142918
CHEMBL453675
CHEMBL503360
CHEMBL453496
CHEMBL454744
CHEMBL501110
CHEMBL451402
CHEMBL506914
CHEMBL446085
CHEMBL509939
CHEMBL508255
CHEMBL499188
CHEMBL1996175
CHEMBL1999460
CHEMBL2007355
C061022
No. 6 No. 70
C00001323 External link 512 Squamocin
CHEMBL41177
CHEMBL502366
CHEMBL453405
CHEMBL452936
C059660
No. 6 No. 70
C00044325 External link 512 Squamone
CHEMBL443714
C064336
No. 6 No. 70
C00044324 External link 512 Squamocin N
CHEMBL13700
CHEMBL62800
CHEMBL145449
CHEMBL452872
CHEMBL503744
CHEMBL484529
No. 6 No. 70
C00030795 External link 512 Motrilin
CHEMBL66691
CHEMBL362807
No. 6 No. 70
C00038456 External link 512 Annotemoyin 1
CHEMBL499513
No. 6 No. 70
C00038457 External link 512 Annotemoyin 2
/ (+)-Annotemoyin 2
CHEMBL499513
No. 6 No. 70
C00038665 External link 512 Bullatencin
/ (+)-Bullatencin
CHEMBL499490
No. 6 No. 70
C00038788 External link 512 cis-Annotemoyin 1
/ (+)-cis-Annotemoyin 1
No. 6 No. 70
C00038790 External link 512 cis-Bullatencin
/ (+)-cis-Bullatencin
CHEMBL499490
No. 6 No. 70
C00040360 External link 512 Squadiolin A
/ (+)-Squadiolin A
CHEMBL448701
No. 6 No. 70
C00040361 External link 512 Squadiolin B
/ (+)-Squadiolin B
CHEMBL500519
No. 6 No. 70
C00040362 External link 512 Squadiolin C
/ (+)-Squadiolin C
No. 6 No. 70
C00040363 External link 512 Squafosacin B
/ (+)-Squafosacin B
CHEMBL442949
No. 6 No. 70
C00040364 External link 512 Squafosacin C
/ (-)-Squafosacin C
CHEMBL451622
No. 6 No. 70
C00040365 External link 512 Squafosacin F
/ (+)-Squafosacin F
CHEMBL311127
CHEMBL396297
CHEMBL452922
CHEMBL2323448
No. 6 No. 70
C00044322 External link 512 Squamocin I
CHEMBL449510
No. 6 No. 70
C00040367 External link 512 Squamostatin A
CHEMBL499780
CHEMBL447119
CHEMBL506139
CHEMBL1818440
No. 6 No. 70
C00040368 External link 512 Squamostatin D
CHEMBL448616
CHEMBL448377
CHEMBL2016769
No. 6 No. 70
C00040606 External link 512 Uvariamicin I
CHEMBL447985
No. 6 No. 70
C00044323 External link 512 Squamocin K
CHEMBL449510
No. 6 No. 70
C00040608 External link 512 Uvariamicin III
CHEMBL447573
CHEMBL442872
No. 6 No. 70
C00044184 External link 512 Glaucanisin
/ (+)-Glaucanisin
CHEMBL64008
No. 6 No. 70
C00044242 External link 512 Mosinone A
CHEMBL453679
No. 6 No. 70
C00044265 External link 512 Neoannonin
/ (+)-Neoannonin
CHEMBL449510
No. 6 No. 70
C00044281 External link 512 Parviflorin
/ Squamocin E
CHEMBL268185
CHEMBL110333
CHEMBL145222
CHEMBL502162
CHEMBL448258
CHEMBL606053
No. 6 No. 70
C00044319 External link 512 Squamocin B
CHEMBL448742
No. 6 No. 70
C00044320 External link 512 Squamocin D
CHEMBL41177
CHEMBL502366
CHEMBL453405
CHEMBL452936
C088265
No. 6 No. 70
C00044321 External link 512 Squamocin F
No. 6 No. 70
C00040366 External link 512 Squafosacin G
/ (+)-Squafosacin G
CHEMBL447573
CHEMBL442872
No. 6 No. 70
C00000965 External link 512 Glabranin
CHEMBL253998
CHEMBL488888
5 / 2 / 3 No. 28 No. 14
C00045643 External link 512 Annosquamosin C
/ (-)-Annosquamosin C
No. 203 No. 41
C00045642 External link 512 Annosquamosin B
/ (-)-Annosquamosin B
CHEMBL516819
No. 203 No. 41
C00045520 External link 512 16alpha,17-Dihydroxy-ent-kauran-19-oic acid
/ (-)-16alpha,17-Dihydroxy-ent-kauran-19-oic acid
CHEMBL490353
CHEMBL517155
CHEMBL519801
CHEMBL482613
No. 203 No. 41
C00045647 External link 512 Annosquamosin G
No. 203 No. 41
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00045644 External link 512 Annosquamosin D
/ (-)-Annosquamosin D
CHEMBL507436
No. 925
C00045646 External link 512 Annosquamosin F
/ (-)-Annosquamosin F
No. 925
C00045645 External link 512 Annosquamosin E
/ (-)-Annosquamosin E
No. 925
C00000881 External link 512 Cunabic acid
/ ent-Kaurenoic acid
/ ent-Kaur-16-en-19-oic acid
CHEMBL523791
CHEMBL480983
CHEMBL1076299
CHEMBL1968150
C051436
1 / 0 / 0 No. 1235 No. 41
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00045641 External link 512 Annomosin A
/ (-)-Annomosin A
No. 4781

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000965 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000881 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00000965 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000965 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000965 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000965 0 / 1
O00255 Menin Unclassified protein C00003110 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255

KEGG DISEASE (10)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)