Swietenia mahagoni
Species
KNApSAcK Entry
| Organism name | Swietenia mahagoni |
|---|---|
| Genus | Swietenia |
| Family | Meliaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Swietenia mahagoni |
|---|---|
| Linked NCBI taxonomy ID | 459165 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Meliaceae |
|---|---|
| ID | 43707 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (20)
| Species | Activity |
|---|---|
| Swietenia mahagoni (L.) Jacq. | Abortifacient |
| Swietenia mahagoni (L.) Jacq. | Antiaggregant |
| Swietenia mahagoni (L.) Jacq. | Antimalarial |
| Swietenia mahagoni (L.) Jacq. | AntiPAF |
| Swietenia mahagoni (L.) Jacq. | Antiproliferant |
| Swietenia mahagoni (L.) Jacq. | Antiseptic |
| Swietenia mahagoni (L.) Jacq. | Antithrombic |
| Swietenia mahagoni (L.) Jacq. | Aphrodisiac |
| Swietenia mahagoni (L.) Jacq. | Astringent |
| Swietenia mahagoni (L.) Jacq. | Bactericide |
| Swietenia mahagoni (L.) Jacq. | Emmenagogue |
| Swietenia mahagoni (L.) Jacq. | Febrifuge |
| Swietenia mahagoni (L.) Jacq. | Fungicide |
| Swietenia mahagoni (L.) Jacq. | Hemostat |
| Swietenia mahagoni (L.) Jacq. | Insecticide |
| Swietenia mahagoni (L.) Jacq. | Orexigenic |
| Swietenia mahagoni (L.) Jacq. | PAF-Inhibitor |
| Swietenia mahagoni (L.) Jacq. | Purgative |
| Swietenia mahagoni (L.) Jacq. | Tonic |
| Swietenia mahagoni (L.) Jacq. | Vulnerary |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00048185
|
Swietmanin J
/ (+)-Swietmanin J |
CHEMBL1081400
|
No. 102 |
|
||||
|
C00048184
|
Swietmanin I
/ (+)-Swietmanin I |
CHEMBL1075776
|
No. 102 |
|
||||
|
C00048183
|
Swietmanin H
/ (+)-Swietmanin H |
CHEMBL1081392
|
No. 102 |
|
||||
|
C00037373
|
Khayasin T
|
No. 102 |
|
|||||
|
C00039764
|
Mexicanolide
|
CHEMBL1080142
CHEMBL1398245 CHEMBL1979074 |
3 / 2 / 4 | No. 102 |
|
|||
|
C00040957
|
Fissinolide
|
CHEMBL1081604
CHEMBL1519828 |
3 / 2 / 4 | No. 102 |
|
|||
|
C00048182
|
Swietmanin G
/ (+)-Swietmanin G |
CHEMBL1075775
|
No. 102 |
|
||||
|
C00048181
|
Swietmanin F
/ (-)-Swietmanin F |
No. 102 |
|
|||||
|
C00047650
|
2,3-Dihydroxy-3-deoxymexicanolide
|
No. 102 |
|
|||||
|
C00047657
|
2-Hydroxyfissinolide
|
CHEMBL1808137
|
No. 102 |
|
||||
|
C00048180
|
Swietmanin E
/ (-)-Swietmanin E |
No. 102 |
|
|||||
|
C00048179
|
Swietmanin D
/ (-)-Swietmanin D |
No. 102 |
|
|||||
|
C00048177
|
Swietmanin B
/ (-)-Swietmanin B |
CHEMBL1075766
|
No. 102 |
|
||||
|
C00048178
|
Swietmanin C
/ (-)-Swietmanin C |
CHEMBL1075767
|
No. 102 |
|
||||
|
C00048119
|
Seneganolide A
|
No. 102 |
|
|||||
|
C00048176
|
Swietmanin A
/ (-)-Swietmanin A |
CHEMBL1075765
|
No. 102 |
|
||||
|
C00034777
|
7-Ketogedunin
/ 7-Deacetoxy-7-oxogedunin |
CHEMBL374788
CHEMBL452232 CHEMBL1512460 |
6 / 13 / 43 | No. 204 | No. 51 |
|
||
|
C00047945
|
Khivorin
|
CHEMBL1075850
CHEMBL1434220 |
3 / 4 / 2 | No. 536 |
|
|||
|
C00047661
|
3-Deacetylkhivorin
|
CHEMBL1075818
CHEMBL1447318 CHEMBL2332194 |
5 / 6 / 7 | No. 536 |
|
|||
|
C00047659
|
3,7-Dideacetylkhivorin
|
CHEMBL1081405
CHEMBL2332202 |
No. 536 |
|
||||
|
C00047648
|
1-Deacetylkhivorin
|
No. 536 |
|
|||||
|
C00047689
|
7-Deacetylkhivorin
|
CHEMBL1075851
CHEMBL1395215 |
3 / 0 / 1 | No. 536 |
|
|||
|
C00047632
|
1,3,7-Trideacetylkhivorin
|
CHEMBL1079815
CHEMBL1445173 |
3 / 0 / 1 | No. 536 |
|
|||
|
C00034874
|
Methyl 6-hydroxyangolensate
/ (-)-Methyl 6-hydroxyangolensate |
CHEMBL513679
CHEMBL1080703 CHEMBL1170898 CHEMBL1561374 |
2 / 0 / 1 | No. 1249 |
|
|||
|
C00035129
|
Methyl angolensate
|
CHEMBL483006
CHEMBL1170283 CHEMBL1450493 |
C092741
|
1 / 0 / 1 | No. 1249 |
|
Human Protein / Gene in interactions
8 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00034777 C00034874 C00035129 C00039764 C00040957 C00047632 C00047661 C00047689 C00047945 | 0 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00034777 C00034874 C00039764 C00040957 C00047632 C00047661 C00047689 C00047945 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00034777 C00039764 C00040957 C00047661 | 2 / 3 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00034777 C00047632 C00047689 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00034777 C00047661 | 4 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00047661 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00047945 | 4 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00034777 | 7 / 37 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (44)
| KEGG | name | UniProt |
|---|---|---|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|