Species

KNApSAcK Entry

Organism name Machaerium villosum
Genus Machaerium
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Machaerium villosum
Linked NCBI taxonomy ID 450039
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00009390 External link 512 3'-Methoxydaidzein
CHEMBL450602
No. 3 No. 15
C00009382 External link 512 Isoformononetin
CHEMBL453280
1 / 1 / 1 No. 3 No. 15
C00009389 External link 512 Cyclosin
/ Calycosin
/ 3'-Hydroxyformononetin
CHEMBL241608
10 / 9 / 6 No. 3 No. 15
C00000945 External link 512 Butin
/ 7,3',4'-Trihydroxyflavanone
CHEMBL451168
C051437
No. 25 No. 14
C00009384 External link 512 3'-Hydroxydaidzein
/ 7,3',4'-Trihydroxyisoflavone
CHEMBL13486
C061213
4 / 7 / 4 8 / 0 No. 71 No. 15

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00009389 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00009384 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00009384 0 / 0
P14174 Macrophage migration inhibitory factor Enzyme C00009384 1 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00009389 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00009389 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00009384 5 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00009389 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00009389 0 / 0
P03372 Estrogen receptor NR3A1 C00009382 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00009389 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00009389 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009389 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00009389 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009389 0 / 0

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00009384
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00009384
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00009384
581 BAX, BCL2L4 BCL2-associated X protein C00009384
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00009384
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00009384
847 CAT catalase (EC:1.11.1.6) C00009384
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00009384

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#609338 Carotid intimal medial thickness 1 P37231
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604302 Rheumatoid arthritis, systemic juvenile P14174
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278300 Xanthinuria, type i P47989

KEGG DISEASE (11)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00026 Endometrial Cancer P03372 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00192 Xanthinuria P47989 (related)