PCIDB

Selaginella spp.

Species

KNApSAcK Entry

Organism name Selaginella spp.
Genus
Family
Kingdom

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001015 External link 512 Amentoflavone
CHEMBL63354
C011164
50 / 39 / 29 5 / 0 No. 34 No. 18
C00006493 External link 512 4',7''-Di-O-methylamentoflavone
/ Amentoflavone 4',7''-dimethyl ether
CHEMBL208988
1 / 0 / 0 No. 34 No. 18

Human Protein / Gene in interactions

50 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A C00001015 C00006493 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001015 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001015 3 / 1
O15496 Group 10 secretory phospholipase A2 Enzyme C00001015 0 / 0
P49763 Placenta growth factor Unclassified protein C00001015 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001015 0 / 0
P14555 Phospholipase A2, membrane associated Enzyme C00001015 0 / 0
P43235 Cathepsin K C1A C00001015 1 / 2
P47712 Cytosolic phospholipase A2 Enzyme C00001015 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001015 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001015 2 / 2
P39748 Flap endonuclease 1 Enzyme C00001015 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001015 2 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001015 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001015 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001015 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001015 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00001015 1 / 1
P15692 Vascular endothelial growth factor A Secreted protein C00001015 1 / 2
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00001015 0 / 0
P08253 72 kDa type IV collagenase M10A C00001015 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001015 2 / 2
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001015 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001015 0 / 0
P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Enzyme C00001015 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001015 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001015 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001015 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00001015 0 / 0
P55072 Transitional endoplasmic reticulum ATPase Unclassified protein C00001015 2 / 1
O00255 Menin Unclassified protein C00001015 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001015 1 / 2
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001015 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001015 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001015 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001015 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001015 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001015 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001015 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001015 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001015 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001015 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001015 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001015 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001015 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001015 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001015 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001015 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001015 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001015 2 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001015
1638 DCT, TRP-2, TYRP2 dopachrome tautomerase (EC:5.3.3.12) C00001015
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001015
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001015
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00001015

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P47869
#613954 Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 P55072
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#600274 Frontotemporal dementia; ftd P10636
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#167320 Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 P55072
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#603933 Microvascular complications of diabetes, susceptibility to, 1; mvcd1 P15692
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#265800 Pycnodysostosis P43235
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (29)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00025 Penile cancer P08253 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
P55072 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00018 Gastric cancer P15692 (related)
H00021 Renal cell carcinoma P15692 (marker)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)