Species

KNApSAcK Entry

Organism name Desmanthus illinoensis
Genus Desmanthus
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Desmanthus illinoensis
Linked NCBI taxonomy ID 196648
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005165 External link 512 Sophoraflavonoloside
/ Kaempferol 3-O-sophoroside
/ Kaempferol 3-O-beta-sophoroside
CHEMBL500233
CHEMBL1375795
CHEMBL2032411
C064309
12 / 2 / 2 6 / 4 No. 1 No. 15
C00005730 External link 512 Myricitrin
/ Myricetin 3-O-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnoside
/ Myricetin 3-O-alpha-L-rhamnopyranoside
CHEMBL454576
CHEMBL522983
CHEMBL1599224
C008577
25 / 11 / 11 No. 2 No. 15
C00006042 External link 512 Desmanthin 1
CHEMBL504487
CHEMBL444120
CHEMBL2152656
No. 98
C00006044 External link 512 Myricetin 3-(4''-galloylrhamnoside)
CHEMBL445807
No. 98
C00000114 External link 512 Tryptophol
/ Indole-3-ethanol
CHEMBL226545
C005949
2 / 4 / 2 No. 710 No. 4
C00001411 External link 512 Gramine
CHEMBL254348
C007884
13 / 11 / 15 No. 1385 No. 4

Human Protein / Gene in interactions

39 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001411 C00005165 C00005730 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005165 C00005730 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001411 C00005730 0 / 0
P06746 DNA polymerase beta Enzyme C00005165 C00005730 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005165 C00005730 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005165 C00005730 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005165 C00005730 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005165 C00005730 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005165 C00005730 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005165 C00005730 1 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00001411 C00005730 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005165 C00005730 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001411 0 / 0
O75496 Geminin Unclassified protein C00005165 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000114 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000114 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005730 1 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005730 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00005730 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00005165 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001411 3 / 3
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001411 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001411 0 / 1
P07237 Protein disulfide-isomerase Enzyme C00005730 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005730 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001411 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00005730 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001411 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005730 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001411 3 / 2
Q99700 Ataxin-2 Unclassified protein C00005730 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001411 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005730 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00005730 1 / 1
O00255 Menin Unclassified protein C00001411 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001411 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00005730 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005730 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005730 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00005165
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00005165
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00005165
7097 TLR2, CD282, TIL4 toll-like receptor 2 C00005165
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00005165
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00005165

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003920 Diabetes Mellitus C00005165
D006967 Hypersensitivity C00005165
D007249 Inflammation C00005165
D009369 Neoplasms C00005165