Species

KNApSAcK Entry

Organism name Artemisia caerulescens
Genus Artemisia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Artemisia caerulescens
Linked NCBI taxonomy ID 72336
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001036 External link 512 Diosmetin
/ 4'-Methylluteolin
/ 5,7,3'-Trihydroxy-4'-methoxyflavone
CHEMBL90568
C039602
11 / 12 / 8 5 / 0 No. 3 No. 15
C00003867 External link 512 Velutin
/ Flavoyadorigenin B
/ Luteolin 7,3'-dimethyl ether
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL508292
No. 3 No. 15
C00003365 External link 512 beta-Santonin
/ [3R-(3alpha,3abeta,5aalpha,9balpha)]-3a,5,5a,9b-Tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)-dione
CHEMBL226231
CHEMBL259254
CHEMBL1357930
CHEMBL1570028
CHEMBL1600999
CHEMBL1717567
CHEMBL2103785
14 / 11 / 8 No. 2117 No. 38

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001036 C00003365 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001036 C00003365 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001036 5 / 3
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00003365 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001036 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00001036 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003365 0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00003365 0 / 0
O75496 Geminin Unclassified protein C00003365 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003365 7 / 3
P04150 Glucocorticoid receptor NR3C1 C00003365 0 / 1
Q99700 Ataxin-2 Unclassified protein C00003365 1 / 1
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00001036 4 / 4
P04745 Alpha-amylase 1 Enzyme C00001036 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003365 1 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00001036 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00001036 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003365 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003365 0 / 1
P33527 Multidrug resistance-associated protein 1 drugs C00001036 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001036 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003365 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003365 1 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001036
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001036
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00001036
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001036
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001036

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#174800 Mccune-albright syndrome; mas P63092
#601665 Obesity P37231
#166350 Osseous heteroplasia, progressive; poh P63092
#604229 Peters anomaly Q16678
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (16)

KEGG name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)