Zingiber aromaticum

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Zingiber aromaticum
Genus	Zingiber
Family	Zingiberaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Zingiber
Linked NCBI taxonomy ID	4650
Linked level	genus

Family

Family in NCBI taxonomy	Zingiberaceae
ID	4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Liliopsida
ID	4447

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005140	Afzelin / Kaempferol 3-O-alpha-rhamnoside / Kaempferol 3-O-alpha-L-rhamnopyranoside	CHEMBL240528 CHEMBL515798	C477954	4 / 2 / 2		No. 2	No. 15
C00005861	Kaempferol 3-(3''-acetylrhamnoside) / Kaempferol 3-O-(3'-O-acetyl-alpha-L-rhamnopyranoside)	CHEMBL470048		2 / 1 / 1		No. 2	No. 15
C00001062	Isokaempferide / Kaempferol 3-methyl ether / 5,7,4'-trihydroxy-3-methoxyflavone	CHEMBL165064		19 / 4 / 3		No. 3	No. 15
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00022001	Tricyclohumuladiol	CHEMBL465350				No. 161	No. 38
C00031419	trans-6-Shogaol	CHEMBL25948		8 / 3 / 4		No. 293	No. 32
C00031474	(S)-10-Gingerol / (+)-(S)-[10]-Gingerol	CHEMBL549472		2 / 2 / 0		No. 293	No. 32
C00002748	[6]-Gingerol / (S)-6-Gingerol / (S)-(+)-[6]Gingerol	CHEMBL402978 CHEMBL1950582		4 / 4 / 0		No. 293	No. 32
C00031475	[8]-Gingerol / (S)-8-Gingerol / (+)-[8]-Gingerol	CHEMBL1095671		2 / 2 / 0		No. 293	No. 32
C00031418	trans-10-Shogaol	CHEMBL24226		2 / 2 / 0		No. 293	No. 32
C00019308	Doursterol / Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside	CHEMBL197711 CHEMBL506678 CHEMBL2304043	C011015	5 / 4 / 2	0 / 3	No. 520
C00031442	Zerumbone epoxide					No. 1728
C00012467	Zerumbone	CHEMBL245412	C403304	4 / 2 / 2	27 / 1	No. 2272
C00031538	2,9-Humuladien-6-ol-8-one / (-)-2,9-Humuladien-6-ol-8-one					No. 2272

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001062 C00003672 C00005140 C00005861 C00012467 C00031419	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001062 C00003672 C00005140 C00005861 C00012467 C00031419	0 / 1
P08183	Multidrug resistance protein 1	drug	C00002748 C00003672 C00031418 C00031419 C00031474 C00031475	1 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00002748 C00031418 C00031419 C00031474 C00031475	1 / 0
P06746	DNA polymerase beta	Enzyme	C00001062 C00003672 C00019308	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672 C00019308	0 / 0
P00734	Prothrombin	S1A	C00003672 C00019308	4 / 2
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002748 C00003672	2 / 0
P08047	Transcription factor Sp1	Unclassified protein	C00003672 C00019308	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672 C00019308	0 / 0
Q8NER1	Transient receptor potential cation channel subfamily V member 1	TRPV (Vanilloid)	C00002748 C00031419	0 / 0
P16083	Ribosyldihydronicotinamide dehydrogenase [quinone]	Enzyme	C00005140	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00031419	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001062	0 / 0
P08151	Zinc finger protein GLI1	Unclassified protein	C00012467	0 / 0
P10070	Zinc finger protein GLI2	Unclassified protein	C00012467	1 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00003672	3 / 2
Q9Y253	DNA polymerase eta	Enzyme	C00001062	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00001062	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00031419	0 / 3
P14679	Tyrosinase	Oxidoreductase	C00003672	4 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003672	0 / 1
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00031419	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003672	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001062	0 / 0
P03372	Estrogen receptor	NR3A1	C00003672	1 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003672	1 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00001062	0 / 0
P98170	E3 ubiquitin-protein ligase XIAP	Other cytosolic protein	C00005140	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00001062	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001062	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001062	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001062	0 / 0
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00001062	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
Q07817	Bcl-2-like protein 1	Other cytosolic protein	C00001062	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001062	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001062	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001062	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001062	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003672	1 / 1
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001062	2 / 1

27 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00012467
597	BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1	BCL2-related protein A1	C00012467
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00012467
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00012467
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00012467
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00012467
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00012467
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00012467
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00012467
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00012467
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00012467
9020	MAP3K14, FTDCR1B, HS, HSNIK, NIK	mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25)	C00012467
4314	MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1	matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17)	C00012467
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00012467
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00012467
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00012467
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00012467
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00012467
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00012467
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00012467
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00012467
7132	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60	tumor necrosis factor receptor superfamily, member 1A	C00012467
8717	TRADD, Hs.89862	TNFRSF1A-associated via death domain	C00012467
7185	TRAF1, EBI6, MGC:10353	TNF receptor-associated factor 1	C00012467
7186	TRAF2, MGC:45012, TRAP, TRAP3	TNF receptor-associated factor 2	C00012467
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00012467
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00012467

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions