PCIDB

KNApSAcK Metabolite C00001062

Metabolite

KNApSAcK Entry

id C00001062
Name Isokaempferide / Kaempferol 3-methyl ether / 5,7,4'-trihydroxy-3-methoxyflavone
CAS RN 1592-70-7
Standard InChI InChI=1S/C16H12O6/c1-21-16-14(20)13-11(19)6-10(18)7-12(13)22-15(16)8-2-4-9(17)5-3-8/h2-7,17-19H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O6/c1-21-16-14(20)13-11(19)6-10(18)7-12(13)22-15(16)8-2-4-9(17)5-3-8/h2-7,17-19H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 3

Link

ChEMBL

By standard InChI CHEMBL165064
By standard InChI Main Layer CHEMBL165064

KEGG

By LinkDB C05902

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 12
asterids 11
Liliopsida 1
Euphyllophyta 1

Family

family name count
Asteraceae 9
Fabaceae 9
Lamiaceae 2
Geraniaceae 1
Betulaceae 1
Pteridaceae 1
Zingiberaceae 1
Combretaceae 1

List (25)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia neovernicosa 199150 Fabaceae rosids Viridiplantae
Betula nigra 3508 Betulaceae rosids Viridiplantae
Cassia javanica 508996 Fabaceae rosids Viridiplantae
Centaurea bracteata Scop. 41503 Asteraceae asterids Viridiplantae
Centaurea clementei 41516 Asteraceae asterids Viridiplantae
Chrysothamnus humilis 217578 Asteraceae asterids Viridiplantae
Chrysothamnus nauseosus 71039 Asteraceae asterids Viridiplantae
Combretum quadrangulare 99434 Combretaceae rosids Viridiplantae
Crotalaria madurensis 890033 Fabaceae rosids Viridiplantae
Flourensia hirsuta 191157 Asteraceae asterids Viridiplantae
Flourensia ilicifolia 191157 Asteraceae asterids Viridiplantae
Genista ephedroides 123905 Fabaceae rosids Viridiplantae
Geranium macrorrhizum L. 28963 Geraniaceae rosids Viridiplantae
Haplopappus deserticola 71051 Asteraceae asterids Viridiplantae
Medicago sativa 3879 Fabaceae rosids Viridiplantae
Notholaena standleyi 414630 Pteridaceae Euphyllophyta Viridiplantae
Prosopis glandulosa 102697 Fabaceae rosids Viridiplantae
Prosopis juliflora 13230 Fabaceae rosids Viridiplantae
Prosopis laevigata 364022 Fabaceae rosids Viridiplantae
Rhynchosia rufescens 132460 Fabaceae rosids Viridiplantae
Salvia glutinosa 49211 Lamiaceae asterids Viridiplantae
Salvia yosgadensis 21880 Lamiaceae asterids Viridiplantae
Serratula wolfi 41634 Asteraceae asterids Viridiplantae
Viguiera gardneri 99451 Asteraceae asterids Viridiplantae
Zingiber aromaticum 4650 Zingiberaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL165064 CHEMBL1000806 (1)
1 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL165064 CHEMBL1614321 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL165064 CHEMBL1738312 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL165064 CHEMBL1614079 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL165064 CHEMBL1794486 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL165064 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL165064 CHEMBL1794401 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL165064 CHEMBL1738588 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL165064 CHEMBL1000805 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL165064 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL165064 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL165064 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL165064 CHEMBL2114908 (1)
0 / 0
Q07817 Bcl-2-like protein 1 Other cytosolic protein CHEMBL165064 CHEMBL1614490 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL165064 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL165064 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL165064 CHEMBL1613829 (1) CHEMBL1794433 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL165064 CHEMBL1738442 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL165064 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#114500 Colorectal cancer; crc Q14191
#608902 Drug metabolism, poor, cyp2d6-related P10635
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (3)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00296 Defects in RecQ helicases Q14191 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)