Species

KNApSAcK Entry

Organism name Grindelia tarapacana
Genus Grindelia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Grindelia tarapacana
Linked NCBI taxonomy ID 1114766
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001096 External link 512 Santin
CHEMBL161957
C104803
9 / 7 / 5 No. 3 No. 15
C00004603 External link 512 Penduletin
/ 5,4'-Dihydroxy-3,6,7-trimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL165509
3 / 3 / 0 No. 3 No. 15
C00004638 External link 512 Quercetin 3,7-dimethyl ether
/ 5,3',4'-Trihydroxy-3,7-dimethoxyflavone
/ 2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL164861
C065497
2 / 1 / 2 No. 3 No. 15
C00004694 External link 512 Centaureidin
/ Desmethoxycentaureidine
/ Quercetagetin 3,4',6-trimethyl ether
/ 5,7,3'-Trihydroxy-3,6,4'-trimethoxyflavone
/ 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL77552
C083161
24 / 14 / 6 No. 3 No. 15
C00004646 External link 512 Pachypodol
/ Quercetin 3,3',7-trimethyl ether
/ 5,4'-Dihydroxy-3,7,3'-trimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL165180
C008751
1 / 2 / 0 No. 3 No. 15
C00004640 External link 512 Quercetin 3,4'-dimethyl ether
/ 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone
/ 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3-methoxy-4H-1-benzopyran-4-one
CHEMBL309263
16 / 8 / 2 No. 3 No. 15
C00004704 External link 512 Polycladin
/ Chrysosplenetin
/ Quercetagetin 3,6,7,3'-tetramethyl ether
/ 5,4'-Dihydroxy-3,6,7,3'-tetramethoxyflavone
/ 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL33256
C072749
No. 8 No. 15

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9BVA1 Tubulin beta-2B chain Structural C00004640 C00004694 1 / 0
Q9BUF5 Tubulin beta-6 chain Structural C00004640 C00004694 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001096 C00004694 1 / 1
Q9BQE3 Tubulin alpha-1C chain Unclassified protein C00004640 C00004694 0 / 0
Q6PEY2 Tubulin alpha-3E chain Unclassified protein C00004640 C00004694 0 / 0
Q13885 Tubulin beta-2A chain Structural C00004640 C00004694 0 / 0
P68363 Tubulin alpha-1B chain Unclassified protein C00004640 C00004694 0 / 0
Q13509 Tubulin beta-3 chain Structural C00004640 C00004694 2 / 1
P68371 Tubulin beta-4B chain Structural C00004640 C00004694 0 / 0
O75496 Geminin Unclassified protein C00001096 C00004694 0 / 0
Q71U36 Tubulin alpha-1A chain Structural C00004640 C00004694 1 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001096 C00004694 0 / 0
P07437 Tubulin beta chain Structural C00004640 C00004694 0 / 0
Q3ZCM7 Tubulin beta-8 chain Structural C00004640 C00004694 0 / 0
P04350 Tubulin beta-4A chain Structural C00004640 C00004694 2 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004603 C00004646 2 / 0
Q9H4B7 Tubulin beta-1 chain Structural C00004640 C00004694 1 / 0
P68366 Tubulin alpha-4A chain Structural C00004640 C00004694 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001096 C00004694 1 / 0
Q13748 Tubulin alpha-3C/D chain Structural C00004640 C00004694 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001096 4 / 3
O14763 Tumor necrosis factor receptor superfamily member 10B Unclassified protein C00004640 1 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 C00004694 2 / 2
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001096 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00004694 1 / 1
P15121 Aldose reductase Enzyme C00004603 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00004694 2 / 0
P39748 Flap endonuclease 1 Enzyme C00004694 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00004694 0 / 0
P08183 Multidrug resistance protein 1 drug C00004603 1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001096 1 / 1
P00747 Plasminogen S1A C00004638 1 / 2
P14618 Pyruvate kinase PKM Enzyme C00001096 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001096 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004638 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#614490 Blood group, junior system; jr Q9UNQ0
#114500 Colorectal cancer; crc P84022
#614039 Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 Q13509
#128101 Dystonia 4, torsion, autosomal dominant; dyt4 P04350
#600638 Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a Q13509
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#612244 Inflammatory bowel disease 13; ibd13 P08183
#612438 Leukodystrophy, hypomyelinating, 6; hld6 P04350
#611603 Lissencephaly 3; lis3 Q71U36
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613112 Macrothrombocytopenia, autosomal dominant, tubb1-related Q9H4B7
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#217090 Plasminogen deficiency, type i P00747
#610031 Polymicrogyria, symmetric or asymmetric; pmgysa Q9BVA1
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc O14763
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (12)

KEGG name UniProt
H00223 Inherited thrombophilia P00747 (related)
H01206 Plasminogen deficiency P00747 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00192 Xanthinuria P47989 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00838 Congenital fibrosis of the extraocular muscles (CFEOM) Q13509 (related)
H00268 Lissencephaly (LIS) Q71U36 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)