Gynostemma pentaphyllum
Species
KNApSAcK Entry
| Organism name | Gynostemma pentaphyllum |
|---|---|
| Genus | Gynostemma |
| Family | Cucurbitaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Gynostemma pentaphyllum |
|---|---|
| Linked NCBI taxonomy ID | 182084 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Cucurbitaceae |
|---|---|
| ID | 3650 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (26)
| Species | Activity |
|---|---|
| Gynostemma pentaphyllum (Thunb.) Makino | Adaptogen |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiaggregant |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiatherosclerotic |
| Gynostemma pentaphyllum (Thunb.) Makino | Anticancer |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiedemic |
| Gynostemma pentaphyllum (Thunb.) Makino | Antifibrotic |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiinflammatory |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiischemic |
| Gynostemma pentaphyllum (Thunb.) Makino | Antioxidant |
| Gynostemma pentaphyllum (Thunb.) Makino | Antiradicular |
| Gynostemma pentaphyllum (Thunb.) Makino | Antisenility |
| Gynostemma pentaphyllum (Thunb.) Makino | Antistroke |
| Gynostemma pentaphyllum (Thunb.) Makino | Antithrombic |
| Gynostemma pentaphyllum (Thunb.) Makino | Apoptotic |
| Gynostemma pentaphyllum (Thunb.) Makino | Cardioprotective |
| Gynostemma pentaphyllum (Thunb.) Makino | Cardiotonic |
| Gynostemma pentaphyllum (Thunb.) Makino | Chemopreventive |
| Gynostemma pentaphyllum (Thunb.) Makino | Hematopoetic |
| Gynostemma pentaphyllum (Thunb.) Makino | Hepalipidemic |
| Gynostemma pentaphyllum (Thunb.) Makino | Hypotensive |
| Gynostemma pentaphyllum (Thunb.) Makino | Immunomodulator |
| Gynostemma pentaphyllum (Thunb.) Makino | Immunostimulant |
| Gynostemma pentaphyllum (Thunb.) Makino | Leukocytogenic |
| Gynostemma pentaphyllum (Thunb.) Makino | NO-Genic |
| Gynostemma pentaphyllum (Thunb.) Makino | Radioprotective |
| Gynostemma pentaphyllum (Thunb.) Makino | SOD-Genic |
Metabolite list (21)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00043565
|
Gypenoside XLVI
|
No. 11 | No. 51 |
|
||||
|
C00003524
|
Glypenoside XXV
|
No. 11 | No. 51 |
|
||||
|
C00030396
|
Gypenoside IV
/ Ginsenoside Rb3 |
CHEMBL449303
CHEMBL507688 CHEMBL452438 |
C044463
|
2 / 0 / 0 | No. 11 | No. 51 |
|
|
|
C00030398
|
Ginsenoside Rd
|
CHEMBL473659
|
C049863
|
2 / 0 / 0 | 0 / 1 | No. 11 | No. 51 |
|
|
C00031837
|
Gylongiposide I
/ (-)-Gylongiposide I |
No. 11 | No. 51 |
|
||||
|
C00031841
|
Gypenoside LXIX
/ (+)-Gypenoside LXIX |
No. 11 | No. 51 |
|
||||
|
C00031842
|
Gypenoside XLVIII
|
No. 11 | No. 51 |
|
||||
|
C00043564
|
Gypenoside XLIX
/ (-)-Gypenoside XLIX |
No. 11 | No. 51 |
|
||||
|
C00043563
|
Gypenoside XLII
|
No. 11 | No. 51 |
|
||||
|
C00043561
|
Gypenoside LXXI
|
No. 11 | No. 51 |
|
||||
|
C00043558
|
Gypenoside LVI
|
No. 11 | No. 51 |
|
||||
|
C00043559
|
Gypenoside LVII
|
No. 11 | No. 51 |
|
||||
|
C00001110
|
Vitexin
/ Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
CHEMBL487417
CHEMBL1332209 CHEMBL1357921 |
16 / 4 / 8 | No. 22 | No. 15 |
|
||
|
C00043557
|
Gynoside E
/ (+)-Gynoside E |
No. 32 | No. 51 |
|
||||
|
C00043556
|
Gynoside D
/ (+)-Gynoside D |
No. 32 | No. 51 |
|
||||
|
C00043560
|
Gypenoside LX
|
No. 32 | No. 51 |
|
||||
|
C00043554
|
Gynoside B
/ (+)-Gynoside B |
No. 32 | No. 51 |
|
||||
|
C00043555
|
Gynoside C
/ (-)-Gynoside C |
No. 32 | No. 51 |
|
||||
|
C00043553
|
Gynoside A
/ (-)-Gynoside A |
No. 32 | No. 51 |
|
||||
|
C00043562
|
Gypenoside LXXVII
|
No. 32 | No. 51 |
|
||||
|
C00043552
|
Gynosaponin TN-1
|
No. 99 |
|
Human Protein / Gene in interactions
18 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11387 | DNA topoisomerase 1 | Isomerase | C00030396 C00030398 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00030396 C00030398 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001110 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001110 | 1 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001110 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001110 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00001110 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001110 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001110 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001110 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001110 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001110 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001110 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001110 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001110 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001110 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001110 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001110 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (4)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|