PCIDB

Cinchona spp.

Species

KNApSAcK Entry

Organism name Cinchona spp.
Genus Cinchona
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cinchona
Linked NCBI taxonomy ID 43462
Linked level genus

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002858 External link 512 Purpurin 1-methyl ether
No. 41 No. 62
C00002786 External link 512 Alizarin 2-methyl ether
/ 1-Hydroxy-2-methoxyanthraquinone
CHEMBL451977
6 / 9 / 11 No. 41 No. 62
C00002814 External link 512 Digiferruginol
CHEMBL495276
C048303
No. 41 No. 62
C00001128 External link 512 Quinovose
/ Epifucose
/ 6-Deoxy-alpha-D-glucose
CHEMBL273741
CHEMBL469449
CHEMBL609880
CHEMBL1338347
CHEMBL2093892
8 / 3 / 5 No. 1283

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001128 1 / 0
P10323 Acrosin S1A C00001128 0 / 0
P04066 Tissue alpha-L-fucosidase Enzyme C00001128 1 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001128 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002786 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001128 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002786 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001128 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002786 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001128 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001128 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002786 4 / 3
O00255 Menin Unclassified protein C00002786 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002786 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#230000 Fucosidosis P04066
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (16)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00141 Fucosidosis P04066 (related)
H00422 Glycoproteinoses P04066 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)