Species

KNApSAcK Entry

Organism name Aconitum napellus
Genus Aconitum
Family Ranunculaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Aconitum napellus
Linked NCBI taxonomy ID 112591
Linked level species

Family

Family in NCBI taxonomy Ranunculaceae
ID 3440

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Natural Activity

List (24)

Species Activity
Aconitum napellus L. Analgesic
Aconitum napellus L. Anesthetic
Aconitum napellus L. Antiinflammatory
Aconitum napellus L. Antineuralgic
Aconitum napellus L. Antipyretic
Aconitum napellus L. Antiseptic
Aconitum napellus L. Arrhythmigenic
Aconitum napellus L. Bradycardic
Aconitum napellus L. Cardiotonic
Aconitum napellus L. Cardiotoxic
Aconitum napellus L. Diaphoretic
Aconitum napellus L. Diuretic
Aconitum napellus L. Emetic
Aconitum napellus L. Hypotensive
Aconitum napellus L. Immunomodulator
Aconitum napellus L. Insecticide
Aconitum napellus L. Mydriatic
Aconitum napellus L. Narcotic
Aconitum napellus L. Paralytic
Aconitum napellus L. Pediculicide
Aconitum napellus L. Poison
Aconitum napellus L. Positive Inotropic
Aconitum napellus L. Sialagogue
Aconitum napellus L. toxic

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00013800 External link 512 Kaempferol 3-(6'''-(E)-p-coumaroylglucosyl)-(1->2)-glucoside-7-rhamnoside
/ 7-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-3-[[2-O-[6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-beta-D-glucopyranosyl]-beta-D-glucopyranosyl]oxy]-4H-1-benzopyran-4-one
No. 7 No. 15
C00013886 External link 512 Quercetin 3-(6''-(E)-p-coumaroylsophoroside)-7-rhamnoside
/ 7-[(6-Deoxy-alpha-L-mannopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-3-[[2-O-beta-D-glucopyranosyl-6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-beta-D-glucopyranosyl]oxy]-5-hydroxy-4H-1-benzopyran-4-one
No. 7 No. 15
C00024806 External link 512 12-Epiacetyldehydronapelline
/ 12-epi-Acetyldehydronapelline
/ 12-Epidehydronapelline 12-acetate
No. 124 No. 10
C00001656 External link 512 Napelline
/ Luciculine
CHEMBL1487558
CHEMBL1741394
C109326
9 / 3 / 5 No. 124 No. 10
C00001654 External link 512 Mesaconitine
CHEMBL400315
CHEMBL2062951
C019470
No. 138 No. 10
C00001644 External link 512 Hypaconitine
CHEMBL400315
CHEMBL2062951
C058309
7 / 0 No. 138 No. 10
C00001611 External link 512 Aconitine
CHEMBL1320549
CHEMBL1434120
CHEMBL1597605
CHEMBL1719550
CHEMBL1979562
CHEMBL2103747
D000157
91 / 49 / 41 9 / 6 No. 138 No. 10
C00001177 External link 512 cis-Aconitic acid
CHEMBL347285
CHEMBL153658
8 / 6 / 7 No. 7916

Human Protein / Gene in interactions

98 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001177 C00001611 C00001656 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001177 C00001611 C00001656 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001177 C00001611 C00001656 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001177 C00001611 C00001656 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001177 C00001611 C00001656 0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001656 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001611 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00001611 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001611 0 / 0
P29466 Caspase-1 C14 C00001611 0 / 0
P17252 Protein kinase C alpha type Alpha C00001611 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001611 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001611 2 / 2
P02545 Prelamin-A/C Unclassified protein C00001611 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00001177 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00001611 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001611 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001611 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001611 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001611 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001611 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001611 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001611 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001611 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001611 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001611 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001611 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001611 2 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001611 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00001611 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001611 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001611 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001611 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001611 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001611 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001611 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001611 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001611 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001611 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001611 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001611 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001611 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001611 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001611 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001611 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001611 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001611 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001611 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001611 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001611 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001611 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001611 0 / 0
P08311 Cathepsin G S1A C00001611 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001611 1 / 0
P03956 Interstitial collagenase M10A C00001611 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001611 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00001656 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001656 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001611 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001611 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001611 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001611 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001611 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001611 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001611 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001611 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001611 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001611 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001611 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001611 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001611 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001611 2 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001611 0 / 3
P08246 Neutrophil elastase S1A C00001611 2 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001611 0 / 0
P03372 Estrogen receptor NR3A1 C00001611 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001611 1 / 0
P22303 Acetylcholinesterase Hydrolase C00001611 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001611 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001611 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001611 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001611 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001611 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00001611 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00001611 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001611 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001611 2 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001611 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001611 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001611 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001611 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001611 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001611 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00001611 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001611 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001177 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001656 0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein C00001177 1 / 2

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001611 C00001644
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00001611 C00001644
1558 CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) C00001611 C00001644
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00001611 C00001644
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001611 C00001644
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001611 C00001644
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001644
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00001611
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00001611
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00001611

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (54)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (47)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001145 Arrhythmias, Cardiac C00001611
D001281 Atrial Fibrillation C00001611
D001282 Atrial Flutter C00001611
D009361 Neoplasm Invasiveness C00001611
D016171 Torsades de Pointes C00001611
D014693 Ventricular Fibrillation C00001611