Species

KNApSAcK Entry

Organism name Neodilsea yendoana
Genus
Family
Kingdom

NCBI taxonomy

Entry

Linked NCBI taxonomy name Neodilsea yendoana
Linked NCBI taxonomy ID 142541
Linked level species

Family

Family in NCBI taxonomy Dumontiaceae
ID 31415

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Eukaryota
ID 2759

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001215 External link 512 (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid
CHEMBL460026
D015118
12 / 12 / 10 36 / 17 No. 2002 No. 50

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001215 2 / 0
P11473 Vitamin D3 receptor NR1I1 C00001215 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00001215 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001215 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001215 1 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001215 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001215 2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001215 5 / 3
P13726 Tissue factor Membrane receptor C00001215 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001215 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001215 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001215 0 / 0

36 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00001215
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001215
9370 ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28 adiponectin, C1Q and collagen domain containing C00001215
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001215
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001215
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00001215
958 CD40, Bp50, CDW40, TNFRSF5, p50 CD40 molecule, TNF receptor superfamily member 5 C00001215
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001215
1535 CYBA, p22-PHOX cytochrome b-245, alpha polypeptide C00001215
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00001215
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00001215
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00001215
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001215
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00001215
117159 DCD, AIDD, DCD-1, DSEP, HCAP, PIF dermcidin C00001215
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00001215
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00001215
3593 IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) C00001215
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001215
3558 IL2, IL-2, TCGF, lymphokine interleukin 2 C00001215
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00001215
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001215
3952 LEP, LEPD, OB, OBS leptin C00001215
778733 C00001215
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001215
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00001215
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00001215
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001215
5683 PSMA2, HC3, MU, PMSA2, PSC2 proteasome (prosome, macropain) subunit, alpha type, 2 (EC:3.4.25.1) C00001215
5693 PSMB5, LMPX, MB1, X proteasome (prosome, macropain) subunit, beta type, 5 (EC:3.4.25.1) C00001215
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001215
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001215
56729 RETN, ADSF, FIZZ3, RETN1, RSTN, XCP1 resistin C00001215
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00001215
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00001215
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001215

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (10)

KEGG name UniProt
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000743 Anemia, Hemolytic C00001215
D001145 Arrhythmias, Cardiac C00001215
D002114 Calcinosis C00001215
D002318 Cardiovascular Diseases C00001215
D003327 Coronary Disease C00001215
D003866 Depressive Disorder C00001215
D050171 Dyslipidemias C00001215
D018149 Glucose Intolerance C00001215
D006973 Hypertension C00001215
D015228 Hypertriglyceridemia C00001215
D007333 Insulin Resistance C00001215
D007414 Intestinal Neoplasms C00001215
D048629 Micronuclei, Chromosome-Defective C00001215
D010146 Pain C00001215
D010300 Parkinson Disease C00001215
D012559 Schizophrenia C00001215
D013927 Thrombosis C00001215