Poterium polygamum
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007247
|
Linolenic acid
/ alpha-Linolenic acid / (Z,Z,Z)-Octadeca-9,12,15-trienoic acid |
D017962
|
22 / 5 |
|
||||
|
C00001232
|
Oleic acid
/ (Z)-9-Octadecenoic acid |
CHEMBL8659
CHEMBL460657 |
D019301
|
30 / 19 / 20 | 26 / 9 | No. 184 | No. 68 |
|
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 | No. 367 | No. 68 |
|
Human Protein / Gene in interactions
45 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 C00001232 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001224 C00001232 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00001232 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00001232 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001224 C00001232 | 3 / 3 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00001232 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 C00001232 | 0 / 0 |
| P13726 | Tissue factor | Membrane receptor | C00001224 C00001232 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001224 C00001232 | 5 / 3 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00001232 | 2 / 2 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 C00001232 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00001232 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001224 C00001232 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001232 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001224 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001232 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001232 | 0 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | C00001232 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001232 | 1 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001232 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001232 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001224 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001224 | 11 / 10 |
| Q13315 | Serine-protein kinase ATM | Atypical serine/threonine protein kinase PIKK subfamily | C00001232 | 1 / 4 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 | 0 / 0 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001232 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 | 0 / 0 |
| P07148 | Fatty acid-binding protein, liver | Unclassified protein | C00001232 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001224 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00001232 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001232 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001224 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001224 | 0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001232 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001232 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001232 | 4 / 3 |
| P10275 | Androgen receptor | NR3C4 | C00001224 | 3 / 4 |
| P17252 | Protein kinase C alpha type | Alpha | C00001232 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001232 | 2 / 2 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001224 | 1 / 1 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001232
C00007247
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00001232
C00007247
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00001232
C00007247
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00001232
C00007247
|
| 100136658 |
C00001232
C00007247
|
||
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00007247
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00007247
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00007247
|
| 3992 | FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12 | fatty acid desaturase 1 (EC:1.14.19.-) |
C00007247
|
| 2729 | GCLC, GCL, GCS, GLCL, GLCLC | glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) |
C00007247
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00007247
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00007247
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00007247
|
| 3827 | KNG1, BDK, BK, KNG | kininogen 1 |
C00007247
|
| 9971 | NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 | nuclear receptor subfamily 1, group H, member 4 |
C00007247
|
| 8647 | ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
C00007247
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 1591 | CYP24A1, CP24, CYP24, HCAI, P450-CC24 | cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) |
C00007247
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00007247
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00007247
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00007247
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00007247
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00001232
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00001232
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00001232
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001232
|
| 335 | APOA1 | apolipoprotein A-I |
C00001232
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00001232
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00001232
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00001232
|
| 1869 | E2F1, E2F-1, RBAP1, RBBP3, RBP3 | E2F transcription factor 1 |
C00001232
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00001232
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001232
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001232
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00001232
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00001232
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00001232
|
| 778733 |
C00001232
|
||
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001232
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00001232
|
| 6514 | SLC2A2, GLUT2 | solute carrier family 2 (facilitated glucose transporter), member 2 |
C00001232
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00001232
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001232
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (40)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #208900 | Ataxia-telangiectasia; at |
Q13315
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (40)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
Q13315 (related) |
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
Q13315
(related)
|
| H00064 | Ataxia telangiectasia (AT) |
Q13315
(related)
|
| H00848 | Ataxia with ocular apraxia (AOA) |
Q13315
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
14 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001930 | Brain Injuries |
C00007247
|
| D003866 | Depressive Disorder |
C00007247
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00007247
|
| D007249 | Inflammation |
C00007247
|
| D009422 | Nervous System Diseases |
C00007247
|
| D055371 | Acute Lung Injury |
C00001232
|
| D000860 | Anoxia |
C00001232
|
| D003072 | Cognition Disorders |
C00001232
|
| D005234 | Fatty Liver |
C00001232
|
| D006520 | Hepatitis, Animal |
C00001232
|
| D007333 | Insulin Resistance |
C00001232
|
| D055370 | Lung Injury |
C00001232
|
| D011654 | Pulmonary Edema |
C00001232
|
| D012128 | Respiratory Distress Syndrome, Adult |
C00001232
|