PCIDB

Iris soforana

Species

KNApSAcK Entry

Organism name Iris soforana
Genus Iris
Family Iridaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Iridaceae
Linked NCBI taxonomy ID 26339
Linked level family

Family

Family in NCBI taxonomy Iridaceae
ID 26339

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00009485 External link 512 Irigenin
/ 5,7,3'-Trimethoxy-6,4',5'-trimethoxyisoflavone
CHEMBL487013
No. 3 No. 15
C00019277 External link 512 Soforanarin B,6,4',5'-Trihydroxy-5,7,3'-trimethoxyisoflavone
No. 3 No. 15
C00019276 External link 512 Soforanarin A
/ 5,3'-Dihydroxy-4'-methoxy-6,7-methylenedioxyisoflavone
No. 27 No. 15
C00002539 External link 512 Irilone
/ 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone
No. 27 No. 15
C00009461 External link 512 Nigricin
/ Irisolone
/ 4'-Hydroxy-5-methoxy-6,7-methylenedioxyisoflavone
CHEMBL486826
No. 27 No. 15
C00009862 External link 512 Iriskashmirianin
/ 4'-Hydroxy-5,3'-dimethoxy-6,7-methylenedioxyisoflavone
No. 27 No. 15
C00019278 External link 512 4'-Methoxy nigricin,5-Hydroxy-4'-methoxy-6,7-methylenedioxyisoflavone
No. 27 No. 15
C00009483 External link 512 3'-O-Methyliriskumaonin
/ Iriskumaonin methyl ether
/ 5,3',4'-Trimethoxy-6,7-methylenedioxyisoflavone
No. 27 No. 15
C00003674 External link 512 Stigmasterol
/ beta-Stigmasterol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00001232 External link 512 Oleic acid
/ (Z)-9-Octadecenoic acid
CHEMBL8659
CHEMBL460657
D019301
30 / 19 / 20 26 / 9 No. 184 No. 68
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68

Human Protein / Gene in interactions

50 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 C00001232 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001224 C00001232 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 C00001232 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 C00001232 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001224 C00001232 3 / 3
Q96RI1 Bile acid receptor NR1H4 C00001224 C00001232 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 C00001232 0 / 0
P13726 Tissue factor Membrane receptor C00001224 C00001232 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 C00001232 5 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 C00001232 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 C00001232 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001224 C00001232 0 / 0
O75496 Geminin Unclassified protein C00001224 C00001232 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 C00001232 2 / 2
P11387 DNA topoisomerase 1 Isomerase C00001232 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001224 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001224 0 / 0
P54132 Bloom syndrome protein Enzyme C00001232 1 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001224 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001232 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00001232 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00003674 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001232 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001232 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001224 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001224 3 / 2
P02545 Prelamin-A/C Unclassified protein C00001224 11 / 10
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00001232 1 / 4
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001224 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00001224 0 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00001232 0 / 0
P17252 Protein kinase C alpha type Alpha C00001232 0 / 0
P07148 Fatty acid-binding protein, liver Unclassified protein C00001232 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001224 2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00001232 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001232 0 / 0
P03372 Estrogen receptor NR3A1 C00001224 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00003674 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001224 0 / 1
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001232 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001232 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001232 4 / 3
P10275 Androgen receptor NR3C4 C00001224 3 / 4
P06746 DNA polymerase beta Enzyme C00003674 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001232 2 / 2
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001224 1 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00003674 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00003674 0 / 0

27 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00003674
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00001232
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001232
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00001232
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001232
335 APOA1 apolipoprotein A-I C00001232
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001232
847 CAT catalase (EC:1.11.1.6) C00001232
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001232
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00001232
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001232
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001232
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001232
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00001232
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001232
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00001232
778733 C00001232
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001232
100136658 C00001232
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00001232
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00001232
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00001232
6256 RXRA, NR2B1 retinoid X receptor, alpha C00001232
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00001232
6514 SLC2A2, GLUT2 solute carrier family 2 (facilitated glucose transporter), member 2 C00001232
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00001232
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001232

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (40)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D055371 Acute Lung Injury C00001232
D000860 Anoxia C00001232
D003072 Cognition Disorders C00001232
D005234 Fatty Liver C00001232
D006520 Hepatitis, Animal C00001232
D007333 Insulin Resistance C00001232
D055370 Lung Injury C00001232
D011654 Pulmonary Edema C00001232
D012128 Respiratory Distress Syndrome, Adult C00001232