Species

KNApSAcK Entry

Organism name Callicarpa pilosissima
Genus Callicarpa
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Callicarpa
Linked NCBI taxonomy ID 21922
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (15)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004603 External link 512 Penduletin
/ 5,4'-Dihydroxy-3,6,7-trimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL165509
3 / 3 / 0 No. 3 No. 15
C00003820 External link 512 Acacetin
/ Apigenin 4'-methyl ether
/ 5,7-Dihydroxy-4'-methoxyflavone
CHEMBL243664
C023717
37 / 55 / 72 5 / 0 No. 3 No. 15
C00004713 External link 512 Hexamethylquercetagetin
/ Oxyayanin B trimethyl ether
/ Quercetagetin hexamethyl ether
/ 3,5,6,7,3',4'-Hexamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-3,5,6,7-tetramethoxy-4H-1-benzopyran-4-one
CHEMBL225698
No. 8 No. 15
C00004705 External link 512 Casticin
/ Vitexicarpin
/ Quercetagetin 3,6,7,4'-tetramethyl ether
/ 3,6,7,4'-Tetra-O-methyl-5,3'-dihydroxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL452767
C054133
No. 8 No. 15
C00004712 External link 512 Artemetin
/ 3,6,7,3',4'-Pentamethylquercetagetin
/ Quercetagetin 3,6,7,3',4'-pentamethyl ether
/ 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL225700
C054132
0 / 5 No. 8 No. 15
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00029821 External link 512 Sitostenone
/ beta-Sitostenone
/ Stigmast-4-en-3-one
/ Stigmast-4-ene-3-one
CHEMBL66926
No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00001238 External link 512 Stearic acid
CHEMBL46403
C031183
15 / 17 / 19 6 / 1 No. 184 No. 68
C00047156 External link 512 7-Oxo-abieta-8,11,13-triene
CHEMBL428568
No. 355
C00047148 External link 512 3-Oxo-abieta-8,11,13-triene
CHEMBL560822
No. 760
C00003755 External link 512 Squalene
/ Supraene
/ Spinacene
CHEMBL458402
D013185
1 / 1 / 2 1 / 1 No. 801 No. 50
C00047130 External link 512 (+)-Glaberide I
CHEMBL461277
No. 1969
C00047204 External link 512 Callicarpic acid B
/ (-)-Callicarpic acid B
CHEMBL559707
No. 4560
C00047203 External link 512 Callicarpic acid A
/ (-)-Callicarpic acid A
CHEMBL553670
No. 7025

Human Protein / Gene in interactions

63 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001238 C00003672 C00003820 1 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001238 C00003755 C00003820 1 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 C00003820 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 C00003820 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 C00003820 1 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00003820 C00004603 2 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 C00003820 1 / 0
P04150 Glucocorticoid receptor NR3C1 C00001238 C00003820 0 / 1
P06746 DNA polymerase beta Enzyme C00003672 C00023774 0 / 0
O00255 Menin Unclassified protein C00001238 C00003820 2 / 5
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 C00003820 0 / 1
P08183 Multidrug resistance protein 1 drug C00003672 C00004603 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001238 C00003672 3 / 2
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00001238 3 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00003820 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003820 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003820 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00003820 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00001238 2 / 3
Q9Y3R4 Sialidase-2 Enzyme C00003820 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003820 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003820 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003820 2 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003820 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00003820 4 / 2
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001238 0 / 0
P15121 Aldose reductase Enzyme C00004603 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001238 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00003820 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001238 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001238 2 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00003820 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00003820 4 / 4
P04745 Alpha-amylase 1 Enzyme C00003820 0 / 0
P50750 Cyclin-dependent kinase 9 Cdk9 C00003820 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00003820 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001238 3 / 3
Q99700 Ataxin-2 Unclassified protein C00003820 1 / 1
O15118 Niemann-Pick C1 protein Unclassified protein C00003820 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003820 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001238 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001238 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00003820 4 / 1
P49336 Cyclin-dependent kinase 8 Cdk8 C00003820 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003820 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003820 4 / 3
P10275 Androgen receptor NR3C4 C00003820 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003820 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001238 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00003820 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003820 1 / 1

13 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003820
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00003820
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00003820
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003820
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003820
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001238
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00001238
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001238
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001238
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001238
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001238
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00003755
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (81)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (86)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003072 Cognition Disorders C00001238
D056486 Drug-Induced Liver Injury C00004712
D004487 Edema C00004712
D006099 Granuloma C00004712
D007022 Hypotension C00004712
D007249 Inflammation C00004712
D009203 Myocardial Infarction C00003755