Species

KNApSAcK Entry

Organism name Betonica officinalis
Genus Betonica
Family Lamiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Betonica officinalis
Linked NCBI taxonomy ID 53173
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00004220 External link 512 Scutellarein 7-glucoside
/ Scutellarein 7-O-beta-glucopyranoside
CHEMBL2312737
CHEMBL2312738
CHEMBL2312739
No. 2 No. 15
C00013332 External link 512 5,4'-dihydroxy-7,3',5'-trimethoxyflavone
/ 5-Hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL470242
No. 3 No. 15
C00010569 External link 512 Harpagide
CHEMBL430183
C033250
1 / 0 / 3 No. 64 No. 36
C00010476 External link 512 Allobetonicoside
No. 222
C00002074 External link 512 Stachydrine
CHEMBL394450
CHEMBL1456892
CHEMBL1986864
10 / 8 / 12 No. 2627 No. 1
C00001345 External link 512 (-)-Betonicine
/ 4-Hydroxyproline betaine
CHEMBL1181451
CHEMBL1373466
CHEMBL1996398
7 / 16 / 14 No. 2627 No. 1

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001345 C00002074 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001345 C00002074 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001345 C00002074 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001345 C00002074 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001345 C00002074 0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00002074 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001345 3 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002074 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002074 3 / 2
P02545 Prelamin-A/C Unclassified protein C00001345 11 / 10
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00010569 0 / 3
O00255 Menin Unclassified protein C00002074 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002074 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (26)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)