Species

KNApSAcK Entry

Organism name Polygonum tinctorum
Genus Polygonum
Family Polygonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Polygonum
Linked NCBI taxonomy ID 46786
Linked level genus

Family

Family in NCBI taxonomy Polygonaceae
ID 3615

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005798 External link 512 Gomphrenol 3-glucoside
No. 2 No. 15
C00002200 External link 512 Tryptanthrin
/ Tryptanthrine
/ Couroupitine A
CHEMBL306946
C046243
20 / 22 / 23 2 / 0 No. 1798 No. 7
C00001541 External link 512 Indican
CHEMBL1561942
CHEMBL2063300
C066596
4 / 3 / 7 No. 2078

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00001541 C00002200 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00001541 C00002200 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002200 2 / 0
P02545 Prelamin-A/C Unclassified protein C00002200 11 / 10
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002200 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002200 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00002200 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00002200 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001541 2 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme C00002200 0 / 0
P42858 Huntingtin Unclassified protein C00002200 1 / 1
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00001541 1 / 4
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002200 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002200 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002200 1 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00002200 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002200 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002200 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002200 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002200 0 / 3
P10636 Microtubule-associated protein tau Unclassified protein C00002200 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002200 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002200
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002200

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#208900 Ataxia-telangiectasia; at Q13315
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (30)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)