PCIDB

Brunsvigia littoralis

Species

KNApSAcK Entry

Organism name Brunsvigia littoralis
Genus Brunsvigia
Family Amaryllidaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Brunsvigia
Linked NCBI taxonomy ID 82217
Linked level genus

Family

Family in NCBI taxonomy Amaryllidaceae
ID 4668

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001561 External link 512 Ambelline
/ (-)-Ambelline
CHEMBL1173110
CHEMBL1600436
CHEMBL1980252
1 / 0 / 1 No. 103 No. 4
C00024384 External link 512 Crinine
/ Crinidine
CHEMBL469648
CHEMBL1221864
CHEMBL1971343
3 / 1 / 0 No. 103 No. 4
C00024349 External link 512 Diacetyllycorine
/ 1,2-Diacetyllycorine
/ 1,2-Di-O-acetyllycorine
CHEMBL465295
2 / 1 / 1 No. 860 No. 4
C00001576 External link 512 Lycorine
/ (-)-Lycorine
CHEMBL224745
CHEMBL400092
CHEMBL583716
CHEMBL577635
CHEMBL1592744
CHEMBL1593638
C015330
20 / 24 / 18 5 / 5 No. 1156 No. 4

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22303 Acetylcholinesterase Hydrolase C00001576 C00024349 C00024384 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001561 C00001576 C00024349 0 / 1
P11387 DNA topoisomerase 1 Isomerase C00001576 C00024384 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00001576 C00024384 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001576 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001576 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001576 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001576 2 / 0
P11473 Vitamin D3 receptor NR1I1 C00001576 2 / 3
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001576 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001576 11 / 10
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001576 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001576 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001576 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001576 1 / 1
Q16637 Survival motor neuron protein Unclassified protein C00001576 4 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001576 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001576 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001576 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001576 1 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
896 CCND3 cyclin D3 C00001576
1003 CDH5, 7B4, CD144 cadherin 5, type 2 (vascular endothelium) C00001576
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001576
10507 SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D C00001576
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00001576

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#112100 Yt blood group antigen P22303

KEGG DISEASE (18)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)

Diseases related to CTD interactions

5 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D009325 Nausea C00001576
D009389 Neovascularization, Pathologic C00001576
D010051 Ovarian Neoplasms C00001576
D012772 Shock, Septic C00001576
D014839 Vomiting C00001576