| Organism name | Aconitum variegatum L. |
|---|---|
| Genus | Aconitum |
| Family | Ranunculaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Aconitum |
|---|---|
| Linked NCBI taxonomy ID | 49188 |
| Linked level | genus |
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00001632
|
Delcosine
|
CHEMBL2141282
|
2 / 7 / 3 | No. 31 | No. 10 |
|
||
|
C00001634
|
Delsoline
|
CHEMBL1242534
CHEMBL1474356 CHEMBL2112855 |
C045308
|
8 / 15 / 13 | No. 31 | No. 10 |
|
|
|
C00001649
|
Karakoline
|
CHEMBL1242438
CHEMBL1496845 CHEMBL1513445 CHEMBL1514236 CHEMBL1525359 CHEMBL1872961 |
8 / 14 / 15 | No. 31 | No. 10 |
|
||
|
C00001669
|
Talatisamine
/ Talatizamine |
C069834
|
No. 31 | No. 10 |
|
|||
|
C00035240
|
8-Ethoxysachaconitine
|
No. 31 | No. 10 |
|
||||
|
C00034995
|
14-Acetyltalatizamine
|
No. 31 | No. 10 |
|
||||
|
C00035209
|
16beta-Hydroxycardiopetaline
|
No. 31 | No. 10 |
|
||||
|
C00035205
|
14-Acetylgenicunine B
|
No. 31 | No. 10 |
|
||||
|
C00035206
|
14-O-Acetylsachaconitine
|
No. 31 | No. 10 |
|
||||
|
C00035192
|
10-Hydroxytalatizamine
|
No. 31 | No. 10 |
|
||||
|
C00035208
|
15-veratroyl-17-acetyl-19-oxodictizine
|
No. 689 | No. 41 |
|
||||
|
C00027424
|
N-Methylarmepavine
|
CHEMBL1187350
|
No. 896 |
|
||||
|
C00035422
|
Variegatine
|
No. 1045 | No. 10 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001634 C00001649 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001634 C00001649 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001634 C00001649 | 0 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001634 C00001649 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001634 C00001649 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001634 C00001649 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001632 C00001634 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001632 | 7 / 3 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001634 | 2 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001649 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001649 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|