PCIDB

Delphinium elatum

Species

KNApSAcK Entry

Organism name Delphinium elatum
Genus Delphinium
Family Ranunculaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Delphinium elatum
Linked NCBI taxonomy ID 46247
Linked level species

Family

Family in NCBI taxonomy Ranunculaceae
ID 3440

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00024870 External link 512 Delatisine
/ (+)-Delatisine
No. 121 No. 10
C00001637 External link 512 Elatine(alkaloid)
CHEMBL2113336
No. 166 No. 10
C00001658 External link 512 Nudicauline
CHEMBL2112854
No. 166 No. 10
C00001655 External link 512 Methyllycaconitine
CHEMBL223494
CHEMBL387362
CHEMBL510275
CHEMBL1412391
CHEMBL1592980
CHEMBL1620703
CHEMBL1869403
CHEMBL2094019
C054634
21 / 12 / 8 15 / 7 No. 166 No. 10
C00001635 External link 512 Deltaline
CHEMBL1378039
CHEMBL1450099
CHEMBL2112845
6 / 2 / 3 No. 764 No. 10

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001635 C00001655 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001635 C00001655 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001635 C00001655 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001635 C00001655 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001635 C00001655 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001655 3 / 3
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001655 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001655 1 / 1
P46098 5-hydroxytryptamine receptor 3A NS C00001655 0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00001655 0 / 0
P30926 Neuronal acetylcholine receptor subunit beta-4 CHRN beta C00001655 0 / 0
P32297 Neuronal acetylcholine receptor subunit alpha-3 CHRN alpha C00001655 1 / 0
P23415 Glycine receptor subunit alpha-1 GLR alpha C00001655 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001655 2 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001635 0 / 0
Q15822 Neuronal acetylcholine receptor subunit alpha-2 CHRN alpha C00001655 1 / 1
Q8WXA8 5-hydroxytryptamine receptor 3C NS C00001655 0 / 0
Q70Z44 5-hydroxytryptamine receptor 3D NS C00001655 0 / 0
O95264 5-hydroxytryptamine receptor 3B NS C00001655 0 / 0
A5X5Y0 5-hydroxytryptamine receptor 3E NS C00001655 0 / 0
Q9UGM1 Neuronal acetylcholine receptor subunit alpha-9 CHRN alpha C00001655 0 / 0
Q9GZZ6 Neuronal acetylcholine receptor subunit alpha-10 CHRN alpha C00001655 0 / 0

15 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00001655
627 BDNF, ANON2, BULN2 brain-derived neurotrophic factor C00001655
1137 CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) C00001655
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00001655
1141 CHRNB2, EFNL3, nAChRB2 cholinergic receptor, nicotinic, beta 2 (neuronal) C00001655
1621 DBH, DBM dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) C00001655
3674 ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) C00001655
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00001655
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001655
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001655
4915 NTRK2, GP145-TrkB, TRKB, trk-B neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) C00001655
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00001655
7054 TH, DYT14, DYT5b, TYH tyrosine hydroxylase (EC:1.14.16.2) C00001655
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001655
7538 ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36 ZFP36 ring finger protein C00001655

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610353 Epilepsy, nocturnal frontal lobe, 4; enfl4 Q15822
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#612052 Smoking as a quantitative trait locus 3; sqtl3 P32297

KEGG DISEASE (8)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
Q15822 (related)
H00769 Hyperekplexia P23415 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

7 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001259 Ataxia C00001655
D001919 Bradycardia C00001655
D006973 Hypertension C00001655
D018908 Muscle Weakness C00001655
D012640 Seizures C00001655
D013610 Tachycardia C00001655
D014202 Tremor C00001655