Aconitum carmichaeli
Species
KNApSAcK Entry
| Organism name | Aconitum carmichaeli |
|---|---|
| Genus | Aconitum |
| Family | Ranunculaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Aconitum carmichaelii |
|---|---|
| Linked NCBI taxonomy ID | 85363 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Ranunculaceae |
|---|---|
| ID | 3440 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001649
|
Karakoline
|
CHEMBL1242438
CHEMBL1496845 CHEMBL1513445 CHEMBL1514236 CHEMBL1525359 CHEMBL1872961 |
8 / 14 / 15 | No. 31 | No. 10 |
|
||
|
C00028990
|
Senbusine A
|
No. 31 | No. 10 |
|
||||
|
C00001669
|
Talatisamine
/ Talatizamine |
C069834
|
No. 31 | No. 10 |
|
|||
|
C00027687
|
Bullatine B
/ 14-O-Acetylneoline |
No. 31 | No. 10 |
|
||||
|
C00027691
|
Fuziline
/ Senbusine C / 15alpha-Hydroxyneoline |
No. 31 | No. 10 |
|
||||
|
C00028288
|
Fuziline
|
No. 31 | No. 10 |
|
||||
|
C00028276
|
Foresaconitine
/ Vilmorrianine C |
No. 138 | No. 10 |
|
||||
|
C00001644
|
Hypaconitine
|
CHEMBL400315
CHEMBL2062951 |
C058309
|
7 / 0 | No. 138 | No. 10 |
|
|
|
C00031692
|
Crassicauline A
|
No. 138 | No. 10 |
|
||||
|
C00031504
|
14-O-Cinnamoylneoline
|
No. 138 | No. 10 |
|
||||
|
C00031503
|
14-O-Anisoylneoline
|
No. 475 | No. 10 |
|
Human Protein / Gene in interactions
8 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001649 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001649 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001649 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00001649 | 1 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001649 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001649 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001649 | 0 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001649 | 0 / 0 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001644
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001644
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00001644
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00001644
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001644
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001644
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001644
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (14)
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|