Ervatamia officinalis
Species
KNApSAcK Entry
| Organism name | Ervatamia officinalis |
|---|---|
| Genus | Ervatamia |
| Family | Apocynaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Apocynaceae |
|---|---|
| Linked NCBI taxonomy ID | 4056 |
| Linked level | family |
Family
| Family in NCBI taxonomy | Apocynaceae |
|---|---|
| ID | 4056 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00025227
|
Voacristine
/ (-)-Voacristine / (-)-Voacangarine |
CHEMBL463317
CHEMBL512646 |
C049505
|
No. 250 | No. 4 |
|
||
|
C00038184
|
3S-Hydroxyconopharyngine
/ 19S-Hydroxyconopharyngine |
CHEMBL518947
|
No. 250 | No. 4 |
|
|||
|
C00025223
|
Voacangine
/ (-)-Voacangine / Carbomethoxyibogaine |
CHEMBL182120
|
C012098
|
No. 250 | No. 4 |
|
||
|
C00040643
|
Voachalotine
|
CHEMBL1368524
|
3 / 7 / 3 | No. 260 | No. 4 |
|
||
|
C00038183
|
19,20-Didehydroervatamine
|
No. 260 | No. 4 |
|
||||
|
C00025059
|
Dehydroepivincamine
/ 14,15-Dehydro-16-epivincamine / 14,15-Didehydro-16-epivincamine / (+)-14,15-Dehydro-16-epivincamine |
No. 452 | No. 4 |
|
||||
|
C00024485
|
12-Methoxyvoaphylline
|
No. 828 |
|
|||||
|
C00024619
|
Voaphyllin
/ Conoflorin / Conoflorine / Voaphylline / (+)-Conoflorine / (+)-Voaphylline |
CHEMBL496674
|
No. 828 |
|
||||
|
C00025196
|
Picrinine
/ Deacetyldeformopicraline |
CHEMBL590510
|
2 / 2 / 2 | No. 946 |
|
|||
|
C00040153
|
Rhazinaline
|
No. 1217 |
|
|||||
|
C00035756
|
Strictamine
|
C022062
|
No. 1217 |
|
||||
|
C00038297
|
6,16-Didehydro-20-episilicine
/ (+)-6,16-Didehydro-20-episilicine |
No. 1292 |
|
|||||
|
C00025941
|
Methuenine
|
CHEMBL520722
CHEMBL487204 |
C042118
|
No. 1292 |
|
|||
|
C00025719
|
16-Epiaffinine
/ 16-epi-Affinine |
No. 1292 |
|
|||||
|
C00025736
|
20-Episilicine
|
No. 1428 |
|
|||||
|
C00038169
|
16,20-Episilicine
/ (-)-16,20-Episilicine |
No. 1428 |
|
|||||
|
C00038310
|
6-Oxo-16,20-episilicine
|
No. 1428 |
|
|||||
|
C00025696
|
(20S)-Hydroxy-1,2-dehydropseudoaspidospermidine
|
No. 1673 |
|
|||||
|
C00001786
|
Vobasine
|
CHEMBL1628271
|
C057239
|
No. 1771 |
|
|||
|
C00026055
|
20-Epidregamine
/ Tabernaemontanin / Tabernaemontanine / (-)-Tabernemontanine / (-)-Tabernaemontanine |
CHEMBL564301
CHEMBL1480853 CHEMBL1594801 CHEMBL1967575 CHEMBL2006905 |
9 / 2 / 3 | No. 1771 |
|
|||
|
C00025859
|
Dregamine
/ (-)-Dregamine / 20-Epitabernemontanine |
CHEMBL564301
CHEMBL1480853 CHEMBL1594801 CHEMBL1967575 CHEMBL2006905 |
9 / 2 / 3 | No. 1771 |
|
|||
|
C00001741
|
Ibogaine
|
CHEMBL222287
CHEMBL1215855 |
D007050
|
1 / 2 / 0 | 0 / 3 | No. 2446 | No. 4 |
|
|
C00038828
|
Conophyllidine
|
CHEMBL455807
|
No. 6986 |
|
Human Protein / Gene in interactions
14 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00025859 C00026055 C00040643 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00025859 C00026055 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00025859 C00026055 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00025859 C00026055 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00025859 C00026055 | 1 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00025859 C00026055 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025859 C00026055 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00025859 C00026055 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00025859 C00026055 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00040643 | 7 / 3 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001741 | 2 / 0 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00025196 | 1 / 1 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00025196 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00040643 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P31645
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
KEGG DISEASE (8)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|