PCIDB

Murraya koenigii

Species

KNApSAcK Entry

Organism name Murraya koenigii
Genus Murraya
Family Rutaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Murraya koenigii
Linked NCBI taxonomy ID 159030
Linked level species

Family

Family in NCBI taxonomy Rutaceae
ID 23513

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (56)

Species Activity
Murraya koenigii (L.) Spreng. Alexeteric
Murraya koenigii (L.) Spreng. Ameba
Murraya koenigii (L.) Spreng. Analgesic
Murraya koenigii (L.) Spreng. Anthelminthic
Murraya koenigii (L.) Spreng. Antibacterial
Murraya koenigii (L.) Spreng. Antibilious
Murraya koenigii (L.) Spreng. Antipyretic
Murraya koenigii (L.) Spreng. Antiseptic
Murraya koenigii (L.) Spreng. Antispasmodic
Murraya koenigii (L.) Spreng. Antiulcer
Murraya koenigii (L.) Spreng. Astringent
Murraya koenigii (L.) Spreng. Bacteria
Murraya koenigii (L.) Spreng. Biliousness
Murraya koenigii (L.) Spreng. Bite
Murraya koenigii (L.) Spreng. Blood
Murraya koenigii (L.) Spreng. Bruise
Murraya koenigii (L.) Spreng. Cancer
Murraya koenigii (L.) Spreng. Carminative
Murraya koenigii (L.) Spreng. Colic
Murraya koenigii (L.) Spreng. Constipation
Murraya koenigii (L.) Spreng. Cramp
Murraya koenigii (L.) Spreng. Dermatosis
Murraya koenigii (L.) Spreng. Diabetes
Murraya koenigii (L.) Spreng. Diarrhea
Murraya koenigii (L.) Spreng. Dysentery
Murraya koenigii (L.) Spreng. Fever
Murraya koenigii (L.) Spreng. Fungus
Murraya koenigii (L.) Spreng. Gastrosis
Murraya koenigii (L.) Spreng. Hemorrhoid
Murraya koenigii (L.) Spreng. Hypertensive
Murraya koenigii (L.) Spreng. Hypoglycemic
Murraya koenigii (L.) Spreng. Immunostimulant
Murraya koenigii (L.) Spreng. Infection
Murraya koenigii (L.) Spreng. Inflammation
Murraya koenigii (L.) Spreng. Itch
Murraya koenigii (L.) Spreng. Laxative
Murraya koenigii (L.) Spreng. Leukemia
Murraya koenigii (L.) Spreng. Leukoderma
Murraya koenigii (L.) Spreng. Malaria
Murraya koenigii (L.) Spreng. Melanoma
Murraya koenigii (L.) Spreng. Nausea
Murraya koenigii (L.) Spreng. Nephrosis
Murraya koenigii (L.) Spreng. Nervousness
Murraya koenigii (L.) Spreng. Pain
Murraya koenigii (L.) Spreng. Phagocytotic
Murraya koenigii (L.) Spreng. Protisticide
Murraya koenigii (L.) Spreng. Snakebite
Murraya koenigii (L.) Spreng. Staphylococcus
Murraya koenigii (L.) Spreng. Stomachic
Murraya koenigii (L.) Spreng. Thirst
Murraya koenigii (L.) Spreng. Tonic
Murraya koenigii (L.) Spreng. Tumor
Murraya koenigii (L.) Spreng. Ulcer
Murraya koenigii (L.) Spreng. Virus
Murraya koenigii (L.) Spreng. vomiting
Murraya koenigii (L.) Spreng. Worm

Metabolite list (20)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00024716 External link 512 Mukolidine
No. 239
C00001753 External link 512 Murrayanine
CHEMBL1689802
No. 239
C00024742 External link 512 Murrayazolinol
No. 239
C00024717 External link 512 Mukoline
No. 239
C00024715 External link 512 Koenoline
CHEMBL503498
No. 239
C00024673 External link 512 2-Methoxy-3-methylcarbazole
CHEMBL1501672
6 / 5 / 7 No. 239
C00024713 External link 512 Isomahanine
CHEMBL498436
20 / 19 / 21 No. 516
C00001745 External link 512 Mahanimbine
CHEMBL495873
3 / 7 / 10 No. 516
C00024719 External link 512 Mukonicine
No. 516
C00027000 External link 512 Murrastifoline F
No. 533
C00024718 External link 512 Mukonal
CHEMBL1077147
No. 751
C00026724 External link 512 Mukonidine
CHEMBL1088190
No. 807
C00026818 External link 512 Mukonine
CHEMBL236143
No. 807
C00026723 External link 512 8,8''-Biskoenigine
CHEMBL434383
2 / 1 / 3 No. 2127
C00024669 External link 512 Curryangin
/ Curryangine
/ Mahanimbidin
/ Mahanimbidine
/ Murrayazoline
/ (+)-Murrayazoline
CHEMBL524719
CHEMBL1971508
No. 2384
C00026892 External link 512 Bismurrayafoline E
No. 2934
C00026726 External link 512 Koeniginequinone B
No. 3454
C00026725 External link 512 Koeniginequinone A
CHEMBL496241
No. 3454
C00002753 External link 512 Isosafrole
CHEMBL487603
C015959
10 / 6 / 10 2 / 0 No. 3773
C00027001 External link 512 Bismurrayaquinone A
No. 5967

Human Protein / Gene in interactions

33 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10636 Microtubule-associated protein tau Unclassified protein C00001745 C00024673 C00024713 4 / 3
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00002753 C00024673 C00024713 1 / 4
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002753 C00024713 0 / 0
O00255 Menin Unclassified protein C00001745 C00024713 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001745 C00024713 1 / 2
O75496 Geminin Unclassified protein C00024673 C00024713 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00002753 0 / 0
P07858 Cathepsin B C1A C00026723 0 / 1
P43235 Cathepsin K C1A C00026723 1 / 2
P39748 Flap endonuclease 1 Enzyme C00024713 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00024673 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00024713 2 / 0
P37840 Alpha-synuclein Unclassified protein C00024713 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00024713 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00002753 1 / 2
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00024713 0 / 0
P08183 Multidrug resistance protein 1 drug C00002753 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00024713 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002753 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00024713 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002753 0 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00024713 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00024713 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00024673 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002753 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002753 0 / 0
P10275 Androgen receptor NR3C4 C00002753 3 / 4
B2RXH2 Lysine-specific demethylase 4E Enzyme C00024673 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00024713 1 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00024713 1 / 1
Q99700 Ataxin-2 Unclassified protein C00024713 1 / 1
P01215 Glycoprotein hormones alpha chain Unclassified protein C00024713 0 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein C00024713 1 / 1

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002753
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002753

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#208900 Ataxia-telangiectasia; at Q13315
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#265800 Pycnodysostosis P43235
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00932 Tropical calcific pancreatitis P07858 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00035 Ewing's sarcoma P11308 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00273 Pycnodysostosis P43235 (related)
H00425 Lysosomal cysteine protease deficiencies P43235 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)